DegronMD

Uniprot ID: Q6P050

Source protein: F-box and leucine-rich protein 22

Source gene: FBXL22

Class: DEG_APCC_DBOX_1

Location: 170:178

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9549

ASA_SCORE: 53.8111

COIL: 0.0933

CONS_SCORE: 0.6648

DSS_SCORE: 0.6202

HELIX: 0.9092

FCONS_SCORE: 1.2598

RIG_SCORE: 0.663

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G188E	DO219773	UCEC	ICGC	ARRGLGSLR	DEG_APCC_DBOX_1	0.0556
p.R171L	SIDM00151	Ovarian Carcinoma	GDSC	ARRGLGSLR	DEG_APCC_DBOX_1	0.8428
p.R171L	ACH-000966	Ovarian Cancer	CCLE	ARRGLGSLR	DEG_APCC_DBOX_1	0.8428
p.G165A	SIDM00613	Glioblastoma	GDSC	ARRGLGSLR	DEG_APCC_DBOX_1	0.1944
p.G165A	ACH-000231	Brain Cancer	CCLE	ARRGLGSLR	DEG_APCC_DBOX_1	0.1944
p.G165A	KALS-1	central_nervous_system	COSMIC	ARRGLGSLR	DEG_APCC_DBOX_1	0.1944
p.A168V	ACH-000990	Endometrial/Uterine Cancer	CCLE	ARRGLGSLR	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6P050	F-box and leucine-rich protein 22	DEG_APCC_DBOX_1	170:178	ARRGLGSLR	APC,CDC20,FZR1	0.9549	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons