DegronMD - Q6P1L8(MRPL14)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E131K	TCGA-38-4632	LUAD	TCGA	IKTPIPT	DEG_SCF_FBW7_1	119:125	Mutation rewiring degron network	0.1667
p.E131K	DO23858	LUAD	ICGC	IKTPIPT	DEG_SCF_FBW7_1	119:125	Mutation rewiring degron network	0.1667
p.N111S	TCGA-98-A53I	LUSC	TCGA	IKTPIPT	DEG_SCF_FBW7_1	119:125	Mutation rewiring degron network	0.1111
p.N111S	DO219182	LUSC	ICGC	IKTPIPT	DEG_SCF_FBW7_1	119:125	Mutation rewiring degron network	0.1111
p.R128H	TCGA-AJ-A2QO	UCEC	TCGA	IKTPIPT	DEG_SCF_FBW7_1	119:125	Mutation rewiring degron network	0.25
p.R128H	DO42177	UCEC	ICGC	IKTPIPT	DEG_SCF_FBW7_1	119:125	Mutation rewiring degron network	0.25
p.V115M	TCGA-AJ-A3BH	UCEC	TCGA	IKTPIPT	DEG_SCF_FBW7_1	119:125	Mutation rewiring degron network	0.2222
p.V115M	DO41638	UCEC	ICGC	IKTPIPT	DEG_SCF_FBW7_1	119:125	Mutation rewiring degron network	0.2222
p.R130L	TCGA-BQ-7051	KIRP	TCGA	IKTPIPT	DEG_SCF_FBW7_1	119:125	Mutation rewiring degron network	0.1944
p.R130L	TCGA-GN-A26C	SKCM	TCGA	IKTPIPT	DEG_SCF_FBW7_1	119:125	Mutation rewiring degron network	0.1944
p.R130L	DO20778	KIRP	ICGC	IKTPIPT	DEG_SCF_FBW7_1	119:125	Mutation rewiring degron network	0.1944
p.R130L	DO37782	SKCM	ICGC	IKTPIPT	DEG_SCF_FBW7_1	119:125	Mutation rewiring degron network	0.1944
p.R118Q	TCGA-FI-A2D5	UCEC	TCGA	IKTPIPT	DEG_SCF_FBW7_1	119:125	Mutation rewiring degron network	0.3056
p.R118Q	DO41331	UCEC	ICGC	IKTPIPT	DEG_SCF_FBW7_1	119:125	Mutation rewiring degron network	0.3056
p.R118Q	SIDM00325	Esophageal Squamous Cell Carcinoma	GDSC	IKTPIPT	DEG_SCF_FBW7_1	119:125	Mutation rewiring degron network	0.3056
p.R118Q	ACH-000694	Esophageal Cancer	CCLE	IKTPIPT	DEG_SCF_FBW7_1	119:125	Mutation rewiring degron network	0.3056
p.R118Q	TE-9	oesophagus	COSMIC	IKTPIPT	DEG_SCF_FBW7_1	119:125	Mutation rewiring degron network	0.3056
p.T117K	DO229038	LICA	ICGC	IKTPIPT	DEG_SCF_FBW7_1	119:125	Mutation rewiring degron network	0.2778
p.R130W	DO49463	PACA	ICGC	IKTPIPT	DEG_SCF_FBW7_1	119:125	Mutation rewiring degron network	0.1944
p.E133D	SIDM00273	Glioblastoma	GDSC	IKTPIPT	DEG_SCF_FBW7_1	119:125	Mutation rewiring degron network	0.1111
p.E133D	ACH-000756	Brain Cancer	CCLE	IKTPIPT	DEG_SCF_FBW7_1	119:125	Mutation rewiring degron network	0.1111
p.E133D	GI-1	central nervous system	COSMIC	IKTPIPT	DEG_SCF_FBW7_1	119:125	Mutation rewiring degron network	0.1111
p.R128C	ACH-001622	Brain Cancer	CCLE	IKTPIPT	DEG_SCF_FBW7_1	119:125	Mutation rewiring degron network	0.25
p.R130Q	ACH-002847	Unknown	CCLE	IKTPIPT	DEG_SCF_FBW7_1	119:125	Mutation rewiring degron network	0.1944

Kaplan plot for MRPL14 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MRPL14

UniProt ID: Q6P1L8

Entrez ID: 64928

Protein name: 39S ribosomal protein L14, mitochondrial (L14mt) (MRP-L14) (39S ribosomal protein L32, mitochondrial) (L32mt) (MRP-L32) (Mitochondrial large ribosomal subunit protein uL14m)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MRPL14 in