DegronMD

Uniprot ID: Q6P1L8

Source protein: 39S ribosomal protein L14, mitochondrial

Source gene: MRPL14

Class: DEG_SCF_FBW7_1

Location: 119:125

E3 ligase: FBXW7

DEGRON score: 0.6428

ASA_SCORE: 36.9

COIL: 0.4414

CONS_SCORE: 0.8145

DSS_SCORE: 0.5015

HELIX: 0.1403

FCONS_SCORE: 1.1927

RIG_SCORE: 0.7917

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E131K	TCGA-38-4632	LUAD	TCGA	IKTPIPT	DEG_SCF_FBW7_1	0.1667
p.E131K	DO23858	LUAD	ICGC	IKTPIPT	DEG_SCF_FBW7_1	0.1667
p.N111S	TCGA-98-A53I	LUSC	TCGA	IKTPIPT	DEG_SCF_FBW7_1	0.1111
p.N111S	DO219182	LUSC	ICGC	IKTPIPT	DEG_SCF_FBW7_1	0.1111
p.R128H	TCGA-AJ-A2QO	UCEC	TCGA	IKTPIPT	DEG_SCF_FBW7_1	0.25
p.R128H	DO42177	UCEC	ICGC	IKTPIPT	DEG_SCF_FBW7_1	0.25
p.V115M	TCGA-AJ-A3BH	UCEC	TCGA	IKTPIPT	DEG_SCF_FBW7_1	0.2222
p.V115M	DO41638	UCEC	ICGC	IKTPIPT	DEG_SCF_FBW7_1	0.2222
p.R130L	TCGA-BQ-7051	KIRP	TCGA	IKTPIPT	DEG_SCF_FBW7_1	0.1944
p.R130L	TCGA-GN-A26C	SKCM	TCGA	IKTPIPT	DEG_SCF_FBW7_1	0.1944
p.R130L	DO20778	KIRP	ICGC	IKTPIPT	DEG_SCF_FBW7_1	0.1944
p.R130L	DO37782	SKCM	ICGC	IKTPIPT	DEG_SCF_FBW7_1	0.1944
p.R118Q	TCGA-FI-A2D5	UCEC	TCGA	IKTPIPT	DEG_SCF_FBW7_1	0.3056
p.R118Q	DO41331	UCEC	ICGC	IKTPIPT	DEG_SCF_FBW7_1	0.3056
p.R118Q	SIDM00325	Esophageal Squamous Cell Carcinoma	GDSC	IKTPIPT	DEG_SCF_FBW7_1	0.3056
p.R118Q	ACH-000694	Esophageal Cancer	CCLE	IKTPIPT	DEG_SCF_FBW7_1	0.3056
p.R118Q	TE-9	oesophagus	COSMIC	IKTPIPT	DEG_SCF_FBW7_1	0.3056
p.T117K	DO229038	LICA	ICGC	IKTPIPT	DEG_SCF_FBW7_1	0.2778
p.R130W	DO49463	PACA	ICGC	IKTPIPT	DEG_SCF_FBW7_1	0.1944
p.E133D	SIDM00273	Glioblastoma	GDSC	IKTPIPT	DEG_SCF_FBW7_1	0.1111
p.E133D	ACH-000756	Brain Cancer	CCLE	IKTPIPT	DEG_SCF_FBW7_1	0.1111
p.E133D	GI-1	central_nervous_system	COSMIC	IKTPIPT	DEG_SCF_FBW7_1	0.1111
p.R128C	ACH-001622	Brain Cancer	CCLE	IKTPIPT	DEG_SCF_FBW7_1	0.25
p.R130Q	ACH-002847	Unknown	CCLE	IKTPIPT	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6P1L8	39S ribosomal protein L14, mitochondrial	DEG_SCF_FBW7_1	119:125	IKTPIPT	FBXW7	0.6428	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons