DegronMD - Q6P387(C16orf46)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S379P	TCGA-A5-A1OF	UCEC	TCGA	PRPVLPSLT	DEG_APCC_DBOX_1	373:381	Mutation altering degron motif	0.5641
p.S379P	DO42568	UCEC	ICGC	PRPVLPSLT	DEG_APCC_DBOX_1	373:381	Mutation altering degron motif	0.5641
p.P388H	TCGA-ER-A1A1	SKCM	TCGA	PRPVLPSLT	DEG_APCC_DBOX_1	373:381	Mutation rewiring degron network	0.1389
p.P388H	DO37413	SKCM	ICGC	PRPVLPSLT	DEG_APCC_DBOX_1	373:381	Mutation rewiring degron network	0.1389
p.T391A	DO230326	COCA	ICGC	PRPVLPSLT	DEG_APCC_DBOX_1	373:381	Mutation rewiring degron network	0.0556
p.P378L	DO222455	ESCA	ICGC	PRPVLPSLT	DEG_APCC_DBOX_1	373:381	Mutation altering degron motif	0.6471
p.R384S	DO222299	GACA	ICGC	PRPVLPSLT	DEG_APCC_DBOX_1	373:381	Mutation rewiring degron network	0.25
p.H382N	DO229009	LICA	ICGC	PRPVLPSLT	DEG_APCC_DBOX_1	373:381	Mutation rewiring degron network	0.3056
p.I387L	DO45261	LIRI	ICGC	PRPVLPSLT	DEG_APCC_DBOX_1	373:381	Mutation rewiring degron network	0.1667
p.V385A	DO45261	LIRI	ICGC	PRPVLPSLT	DEG_APCC_DBOX_1	373:381	Mutation rewiring degron network	0.2222
p.K385N	DO43041	UCEC	ICGC	PRPVLPSLT	DEG_APCC_DBOX_1	373:381	Mutation rewiring degron network	0.2222
p.R383M	DO43186	UCEC	ICGC	PRPVLPSLT	DEG_APCC_DBOX_1	373:381	Mutation blocking phosphorylation signal	0.7222
p.R383M	DO42568	UCEC	ICGC	PRPVLPSLT	DEG_APCC_DBOX_1	373:381	Mutation blocking phosphorylation signal	0.7222
p.V382M	SIDM00837	Colorectal Carcinoma	GDSC	PRPVLPSLT	DEG_APCC_DBOX_1	373:381	Mutation rewiring degron network	0.3056
p.V382M	ACH-000958	Colon/Colorectal Cancer	CCLE	PRPVLPSLT	DEG_APCC_DBOX_1	373:381	Mutation rewiring degron network	0.3056
p.S390C	SIDM00158	Glioblastoma	GDSC	PRPVLPSLT	DEG_APCC_DBOX_1	373:381	Mutation blocking phosphorylation signal	0.5278
p.S390C	ACH-000623	Brain Cancer	CCLE	PRPVLPSLT	DEG_APCC_DBOX_1	373:381	Mutation blocking phosphorylation signal	0.5278

Kaplan plot for C16orf46 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

C16orf46

UniProt ID: Q6P387

Entrez ID: 123775

Protein name: Uncharacterized protein C16orf46

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for C16orf46 in