DegronMD

Uniprot ID: Q6P387

Source protein: Uncharacterized protein C16orf46

Source gene: C16orf46

Class: DEG_APCC_DBOX_1

Location: 373:381

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9156

ASA_SCORE: 72.6333

COIL: 0.8503

CONS_SCORE: 0.7714

DSS_SCORE: 0.1855

HELIX: 0.0543

FCONS_SCORE: 1.0771

RIG_SCORE: 0.785

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S379P	TCGA-A5-A1OF	UCEC	TCGA	PRPVLPSLT	DEG_APCC_DBOX_1	0.5641
p.S379P	DO42568	UCEC	ICGC	PRPVLPSLT	DEG_APCC_DBOX_1	0.5641
p.P388H	TCGA-ER-A1A1	SKCM	TCGA	PRPVLPSLT	DEG_APCC_DBOX_1	0.1389
p.P388H	DO37413	SKCM	ICGC	PRPVLPSLT	DEG_APCC_DBOX_1	0.1389
p.T391A	DO230326	COCA	ICGC	PRPVLPSLT	DEG_APCC_DBOX_1	0.0556
p.P378L	DO222455	ESCA	ICGC	PRPVLPSLT	DEG_APCC_DBOX_1	0.6471
p.R384S	DO222299	GACA	ICGC	PRPVLPSLT	DEG_APCC_DBOX_1	0.25
p.H382N	DO229009	LICA	ICGC	PRPVLPSLT	DEG_APCC_DBOX_1	0.3056
p.I387L	DO45261	LIRI	ICGC	PRPVLPSLT	DEG_APCC_DBOX_1	0.1667
p.V385A	DO45261	LIRI	ICGC	PRPVLPSLT	DEG_APCC_DBOX_1	0.2222
p.K385N	DO43041	UCEC	ICGC	PRPVLPSLT	DEG_APCC_DBOX_1	0.2222
p.R383M	DO43186	UCEC	ICGC	PRPVLPSLT	DEG_APCC_DBOX_1	0.7222
p.R383M	DO42568	UCEC	ICGC	PRPVLPSLT	DEG_APCC_DBOX_1	0.7222
p.V382M	SIDM00837	Colorectal Carcinoma	GDSC	PRPVLPSLT	DEG_APCC_DBOX_1	0.3056
p.V382M	ACH-000958	Colon/Colorectal Cancer	CCLE	PRPVLPSLT	DEG_APCC_DBOX_1	0.3056
p.S390C	SIDM00158	Glioblastoma	GDSC	PRPVLPSLT	DEG_APCC_DBOX_1	0.5278
p.S390C	ACH-000623	Brain Cancer	CCLE	PRPVLPSLT	DEG_APCC_DBOX_1	0.5278

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6P387	Uncharacterized protein C16orf46	DEG_APCC_DBOX_1	373:381	PRPVLPSLT	APC,CDC20,FZR1	0.9156	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons