DegronMD - Q6P3R8(NEK5)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V523L	TCGA-22-4613	LUSC	TCGA	LPVHQD	LIG_APCC_ABBA_1	510:515	Mutation rewiring degron network	0.1111
p.V523L	DO26468	LUSC	ICGC	LPVHQD	LIG_APCC_ABBA_1	510:515	Mutation rewiring degron network	0.1111
p.K507N	TCGA-DR-A0ZM	CESC	TCGA	LPVHQD	LIG_APCC_ABBA_1	510:515	Mutation substituting flanking lysine	0.3611
p.K507N	DO6254	CESC	ICGC	LPVHQD	LIG_APCC_ABBA_1	510:515	Mutation substituting flanking lysine	0.3611
p.P511S	TCGA-IB-7651	PAAD	TCGA	LPVHQD	LIG_APCC_ABBA_1	510:515	Mutation altering degron motif	0.5641
p.P511S	DO46657	PAAD	ICGC	LPVHQD	LIG_APCC_ABBA_1	510:515	Mutation altering degron motif	0.5641
p.K507R	DO232224	PBCA	ICGC	LPVHQD	LIG_APCC_ABBA_1	510:515	Mutation substituting flanking lysine	0.3611
p.H513Y	DO229453	SKCA	ICGC	LPVHQD	LIG_APCC_ABBA_1	510:515	Mutation altering degron motif	0.6118
p.T502S	SIDM00444	Esophageal Carcinoma	GDSC	LPVHQD	LIG_APCC_ABBA_1	510:515	Mutation rewiring degron network	0.1111
p.T502S	ACH-001368	Esophageal Cancer	CCLE	LPVHQD	LIG_APCC_ABBA_1	510:515	Mutation rewiring degron network	0.1111
p.T502S	OACM5-1	oesophagus	COSMIC	LPVHQD	LIG_APCC_ABBA_1	510:515	Mutation rewiring degron network	0.1111
p.D515N	SIDM00596	Endometrial Carcinoma	GDSC	LPVHQD	LIG_APCC_ABBA_1	510:515	Mutation altering degron motif	0.6932
p.D515N	SIDM00306	Non-Small Cell Lung Carcinoma	GDSC	LPVHQD	LIG_APCC_ABBA_1	510:515	Mutation altering degron motif	0.6932
p.D515N	ACH-000635	Ovarian Cancer	CCLE	LPVHQD	LIG_APCC_ABBA_1	510:515	Mutation altering degron motif	0.6932
p.D515N	ACH-000672	Lung Cancer	CCLE	LPVHQD	LIG_APCC_ABBA_1	510:515	Mutation altering degron motif	0.6932
p.D515N	ACH-000941	Endometrial/Uterine Cancer	CCLE	LPVHQD	LIG_APCC_ABBA_1	510:515	Mutation altering degron motif	0.6932
p.D515N	ACH-000954	Endometrial/Uterine Cancer	CCLE	LPVHQD	LIG_APCC_ABBA_1	510:515	Mutation altering degron motif	0.6932
p.D515N	ACH-001517	Endometrial/Uterine Cancer	CCLE	LPVHQD	LIG_APCC_ABBA_1	510:515	Mutation altering degron motif	0.6932
p.D515N	ACH-001856	Bile Duct Cancer	CCLE	LPVHQD	LIG_APCC_ABBA_1	510:515	Mutation altering degron motif	0.6932
p.D515N	IA-LM	lung	COSMIC	LPVHQD	LIG_APCC_ABBA_1	510:515	Mutation altering degron motif	0.6932
p.D515N	HEC-1	endometrium	COSMIC	LPVHQD	LIG_APCC_ABBA_1	510:515	Mutation altering degron motif	0.6932
p.T502P	ACH-001091	Colon/Colorectal Cancer	CCLE	LPVHQD	LIG_APCC_ABBA_1	510:515	Mutation rewiring degron network	0.1111

Kaplan plot for NEK5 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NEK5

UniProt ID: Q6P3R8

Entrez ID: 341676

Protein name: Serine/threonine-protein kinase Nek5 (EC 2.7.11.1) (Never in mitosis A-related kinase 5) (NimA-related protein kinase 5)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for NEK5 in