DegronMD

Uniprot ID: Q6P3R8

Source protein: Serine/threonine-protein kinase Nek5

Source gene: NEK5

Class: LIG_APCC_ABBA_1

Location: 510:515

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7725

ASA_SCORE: 98.55

COIL: 0.8733

CONS_SCORE: 0.4098

DSS_SCORE: 0.5017

HELIX: 0.102

FCONS_SCORE: 1.0108

RIG_SCORE: 0.7085

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V523L	TCGA-22-4613	LUSC	TCGA	LPVHQD	LIG_APCC_ABBA_1	0.1111
p.V523L	DO26468	LUSC	ICGC	LPVHQD	LIG_APCC_ABBA_1	0.1111
p.K507N	TCGA-DR-A0ZM	CESC	TCGA	LPVHQD	LIG_APCC_ABBA_1	0.3611
p.K507N	DO6254	CESC	ICGC	LPVHQD	LIG_APCC_ABBA_1	0.3611
p.P511S	TCGA-IB-7651	PAAD	TCGA	LPVHQD	LIG_APCC_ABBA_1	0.5641
p.P511S	DO46657	PAAD	ICGC	LPVHQD	LIG_APCC_ABBA_1	0.5641
p.K507R	DO232224	PBCA	ICGC	LPVHQD	LIG_APCC_ABBA_1	0.3611
p.H513Y	DO229453	SKCA	ICGC	LPVHQD	LIG_APCC_ABBA_1	0.6118
p.T502S	SIDM00444	Esophageal Carcinoma	GDSC	LPVHQD	LIG_APCC_ABBA_1	0.1111
p.T502S	ACH-001368	Esophageal Cancer	CCLE	LPVHQD	LIG_APCC_ABBA_1	0.1111
p.T502S	OACM5-1	oesophagus	COSMIC	LPVHQD	LIG_APCC_ABBA_1	0.1111
p.D515N	SIDM00596	Endometrial Carcinoma	GDSC	LPVHQD	LIG_APCC_ABBA_1	0.6932
p.D515N	SIDM00306	Non-Small Cell Lung Carcinoma	GDSC	LPVHQD	LIG_APCC_ABBA_1	0.6932
p.D515N	ACH-000635	Ovarian Cancer	CCLE	LPVHQD	LIG_APCC_ABBA_1	0.6932
p.D515N	ACH-000672	Lung Cancer	CCLE	LPVHQD	LIG_APCC_ABBA_1	0.6932
p.D515N	ACH-000941	Endometrial/Uterine Cancer	CCLE	LPVHQD	LIG_APCC_ABBA_1	0.6932
p.D515N	ACH-000954	Endometrial/Uterine Cancer	CCLE	LPVHQD	LIG_APCC_ABBA_1	0.6932
p.D515N	ACH-001517	Endometrial/Uterine Cancer	CCLE	LPVHQD	LIG_APCC_ABBA_1	0.6932
p.D515N	ACH-001856	Bile Duct Cancer	CCLE	LPVHQD	LIG_APCC_ABBA_1	0.6932
p.D515N	IA-LM	lung	COSMIC	LPVHQD	LIG_APCC_ABBA_1	0.6932
p.D515N	HEC-1	endometrium	COSMIC	LPVHQD	LIG_APCC_ABBA_1	0.6932
p.T502P	ACH-001091	Colon/Colorectal Cancer	CCLE	LPVHQD	LIG_APCC_ABBA_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6P3R8	Serine/threonine-protein kinase Nek5	LIG_APCC_ABBA_1	510:515	LPVHQD	APC,CDC20,FZR1	0.7725	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons