DegronMD - Q6P3X3(TTC27)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S789Y	TCGA-AG-A002	READ	TCGA	VRLNLRGLL	DEG_APCC_DBOX_1	791:799	Mutation rewiring degron network	0.2778
p.L798M	TCGA-B5-A3FC	UCEC	TCGA	VRLNLRGLL	DEG_APCC_DBOX_1	791:799	Mutation altering degron motif	0.5999
p.L798M	DO41871	UCEC	ICGC	VRLNLRGLL	DEG_APCC_DBOX_1	791:799	Mutation altering degron motif	0.5999
p.S781F	TCGA-FR-A7U9	SKCM	TCGA	VRLNLRGLL	DEG_APCC_DBOX_1	791:799	Mutation rewiring degron network	0.0556
p.S781F	DO48546	SKCM	ICGC	VRLNLRGLL	DEG_APCC_DBOX_1	791:799	Mutation rewiring degron network	0.0556
p.N794S	DO51529	PACA	ICGC	VRLNLRGLL	DEG_APCC_DBOX_1	791:799	Mutation altering degron motif	0.5958
p.N794S	SIDM00143	Small Cell Lung Carcinoma	GDSC	VRLNLRGLL	DEG_APCC_DBOX_1	791:799	Mutation altering degron motif	0.5958
p.V791G	SIDM00217	Colorectal Carcinoma	GDSC	VRLNLRGLL	DEG_APCC_DBOX_1	791:799	Mutation altering degron motif	0.6421
p.V791G	ACH-000999	Colon/Colorectal Cancer	CCLE	VRLNLRGLL	DEG_APCC_DBOX_1	791:799	Mutation altering degron motif	0.6421
p.V791G	SNU-1040	large intestine	COSMIC	VRLNLRGLL	DEG_APCC_DBOX_1	791:799	Mutation altering degron motif	0.6421
p.V809M	ACH-001001	Bone Cancer	CCLE	VRLNLRGLL	DEG_APCC_DBOX_1	791:799	Mutation rewiring degron network	0.0556

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons