DegronMD

Uniprot ID: Q6P3X3

Source protein: Tetratricopeptide repeat protein 27

Source gene: TTC27

Class: DEG_APCC_DBOX_1

Location: 791:799

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.547

ASA_SCORE: 39.2111

COIL: 0.0101

CONS_SCORE: 0.443

DSS_SCORE: 0.1516

HELIX: 0.9884

FCONS_SCORE: 1.3626

RIG_SCORE: 0.802

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S789Y	TCGA-AG-A002	READ	TCGA	VRLNLRGLL	DEG_APCC_DBOX_1	0.2778
p.L798M	TCGA-B5-A3FC	UCEC	TCGA	VRLNLRGLL	DEG_APCC_DBOX_1	0.5999
p.L798M	DO41871	UCEC	ICGC	VRLNLRGLL	DEG_APCC_DBOX_1	0.5999
p.S781F	TCGA-FR-A7U9	SKCM	TCGA	VRLNLRGLL	DEG_APCC_DBOX_1	0.0556
p.S781F	DO48546	SKCM	ICGC	VRLNLRGLL	DEG_APCC_DBOX_1	0.0556
p.N794S	DO51529	PACA	ICGC	VRLNLRGLL	DEG_APCC_DBOX_1	0.5958
p.N794S	SIDM00143	Small Cell Lung Carcinoma	GDSC	VRLNLRGLL	DEG_APCC_DBOX_1	0.5958
p.V791G	SIDM00217	Colorectal Carcinoma	GDSC	VRLNLRGLL	DEG_APCC_DBOX_1	0.6421
p.V791G	ACH-000999	Colon/Colorectal Cancer	CCLE	VRLNLRGLL	DEG_APCC_DBOX_1	0.6421
p.V791G	SNU-1040	large_intestine	COSMIC	VRLNLRGLL	DEG_APCC_DBOX_1	0.6421
p.V809M	ACH-001001	Bone Cancer	CCLE	VRLNLRGLL	DEG_APCC_DBOX_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6P3X3	Tetratricopeptide repeat protein 27	DEG_APCC_DBOX_1	791:799	VRLNLRGLL	APC,CDC20,FZR1	0.547	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons