DegronMD - Q6P4I2(WDR73)

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GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.H330N	TCGA-FS-A1ZD	SKCM	TCGA	RGHIFLD	LIG_APCC_ABBAyCdc20_2	328:334	Mutation altering degron motif	0.6312
p.H330N	DO37627	SKCM	ICGC	RGHIFLD	LIG_APCC_ABBAyCdc20_2	328:334	Mutation altering degron motif	0.6312
p.P340T	DO229008	LICA	ICGC	RGHIFLD	LIG_APCC_ABBAyCdc20_2	328:334	Mutation rewiring degron network	0.1667
p.F325V	DO231851	LINC	ICGC	RGHIFLD	LIG_APCC_ABBAyCdc20_2	328:334	Mutation rewiring degron network	0.25
p.I331M	DO227558	PACA	ICGC	RGHIFLD	LIG_APCC_ABBAyCdc20_2	328:334	Mutation altering degron motif	0.6507
p.G329C	DO232224	PBCA	ICGC	RGHIFLD	LIG_APCC_ABBAyCdc20_2	328:334	Mutation altering degron motif	0.6489
p.T326I	SIDM01608	Endometrial Carcinoma	GDSC	RGHIFLD	LIG_APCC_ABBAyCdc20_2	328:334	Mutation rewiring degron network	0.2778
p.T326I	ACH-000990	Endometrial/Uterine Cancer	CCLE	RGHIFLD	LIG_APCC_ABBAyCdc20_2	328:334	Mutation rewiring degron network	0.2778

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons