DegronMD

Uniprot ID: Q6P4I2

Source protein: WD repeat-containing protein 73

Source gene: WDR73

Class: LIG_APCC_ABBAyCdc20_2

Location: 328:334

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.73

ASA_SCORE: 46.4

COIL: 0.6476

CONS_SCORE: 0.5452

DSS_SCORE: 0.4077

HELIX: 0.0341

FCONS_SCORE: 1.1821

RIG_SCORE: 0.7674

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H330N	TCGA-FS-A1ZD	SKCM	TCGA	RGHIFLD	LIG_APCC_ABBAyCdc20_2	0.6312
p.H330N	DO37627	SKCM	ICGC	RGHIFLD	LIG_APCC_ABBAyCdc20_2	0.6312
p.P340T	DO229008	LICA	ICGC	RGHIFLD	LIG_APCC_ABBAyCdc20_2	0.1667
p.F325V	DO231851	LINC	ICGC	RGHIFLD	LIG_APCC_ABBAyCdc20_2	0.25
p.I331M	DO227558	PACA	ICGC	RGHIFLD	LIG_APCC_ABBAyCdc20_2	0.6507
p.G329C	DO232224	PBCA	ICGC	RGHIFLD	LIG_APCC_ABBAyCdc20_2	0.6489
p.T326I	SIDM01608	Endometrial Carcinoma	GDSC	RGHIFLD	LIG_APCC_ABBAyCdc20_2	0.2778
p.T326I	ACH-000990	Endometrial/Uterine Cancer	CCLE	RGHIFLD	LIG_APCC_ABBAyCdc20_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6P4I2	WD repeat-containing protein 73	LIG_APCC_ABBAyCdc20_2	328:334	RGHIFLD	APC,CDC20,FZR1	0.73	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons