DegronMD - Q6P5S7(RNASEK)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S27R	TCGA-D1-A0ZQ	UCEC	TCGA	LAPRRSPTPFFM	DEG_ODPH_VHL_1	29:40	Mutation rewiring degron network	0.2778
p.S27R	DO41879	UCEC	ICGC	LAPRRSPTPFFM	DEG_ODPH_VHL_1	29:40	Mutation rewiring degron network	0.2778
p.L29F	TCGA-DX-A1KU	SARC	TCGA	LAPRRSPTPFFM	DEG_ODPH_VHL_1	29:40	Mutation altering degron motif	0.6981
p.L29F	DO219944	SARC	ICGC	LAPRRSPTPFFM	DEG_ODPH_VHL_1	29:40	Mutation altering degron motif	0.6981
p.S22F	TCGA-EE-A2MJ	SKCM	TCGA	LAPRRSPTPFFM	DEG_ODPH_VHL_1	29:40	Mutation rewiring degron network	0.1389
p.S22F	DO38099	SKCM	ICGC	LAPRRSPTPFFM	DEG_ODPH_VHL_1	29:40	Mutation rewiring degron network	0.1389
p.G28V	DO229022	LICA	ICGC	LAPRRSPTPFFM	DEG_ODPH_VHL_1	29:40	Mutation rewiring degron network	0.3056
p.F21L	DO52146	PAEN	ICGC	LAPRRSPTPFFM	DEG_ODPH_VHL_1	29:40	Mutation rewiring degron network	0.1111
p.F31L	DO43154	UCEC	ICGC	LAPRRSPTPFFM	DEG_ODPH_VHL_1	29:40	Mutation altering degron motif	0.6981
p.A20V	SIDM00333	Endometrial Carcinoma	GDSC	LAPRRSPTPFFM	DEG_ODPH_VHL_1	29:40	Mutation rewiring degron network	0.0833
p.A20V	ACH-000988	Endometrial/Uterine Cancer	CCLE	LAPRRSPTPFFM	DEG_ODPH_VHL_1	29:40	Mutation rewiring degron network	0.0833
p.A20V	MFE-319	endometrium	COSMIC	LAPRRSPTPFFM	DEG_ODPH_VHL_1	29:40	Mutation rewiring degron network	0.0833
p.A30V	SIDM01608	Endometrial Carcinoma	GDSC	LAPRRSPTPFFM	DEG_ODPH_VHL_1	29:40	Mutation altering degron motif	0.6936
p.A30V	ACH-000990	Endometrial/Uterine Cancer	CCLE	LAPRRSPTPFFM	DEG_ODPH_VHL_1	29:40	Mutation altering degron motif	0.6936
p.S37P	HMV-II	skin	COSMIC	LAPRRSPTPFFM	DEG_ODPH_VHL_1	29:40	Mutation altering degron motif	0.6752
p.F42S	HMV-II	skin	COSMIC	LAPRRSPTPFFM	DEG_ODPH_VHL_1	29:40	Mutation rewiring degron network	0.2778

Kaplan plot for RNASEK in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RNASEK

UniProt ID: Q6P5S7

Entrez ID: 440400

Protein name: Ribonuclease kappa (RNase K) (RNase kappa) (EC 3.1.-.-) (V-type proton ATPase subunit f) (V-ATPase subunit f)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RNASEK in