DegronMD

Uniprot ID: Q6P5S7

Source protein: Ribonuclease kappa

Source gene: RNASEK

Class: DEG_ODPH_VHL_1

Location: 29:40

E3 ligase: VHL

DEGRON score: 0.8821

ASA_SCORE: 82.4083

COIL: 0.7568

CONS_SCORE: 0.8705

DSS_SCORE: 0.1338

HELIX: 0.1777

FCONS_SCORE: 1.2916

RIG_SCORE: 0.7411

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S27R	TCGA-D1-A0ZQ	UCEC	TCGA	LAPRRSPTPFFM	DEG_ODPH_VHL_1	0.2778
p.S27R	DO41879	UCEC	ICGC	LAPRRSPTPFFM	DEG_ODPH_VHL_1	0.2778
p.L29F	TCGA-DX-A1KU	SARC	TCGA	LAPRRSPTPFFM	DEG_ODPH_VHL_1	0.6981
p.L29F	DO219944	SARC	ICGC	LAPRRSPTPFFM	DEG_ODPH_VHL_1	0.6981
p.S22F	TCGA-EE-A2MJ	SKCM	TCGA	LAPRRSPTPFFM	DEG_ODPH_VHL_1	0.1389
p.S22F	DO38099	SKCM	ICGC	LAPRRSPTPFFM	DEG_ODPH_VHL_1	0.1389
p.G28V	DO229022	LICA	ICGC	LAPRRSPTPFFM	DEG_ODPH_VHL_1	0.3056
p.F21L	DO52146	PAEN	ICGC	LAPRRSPTPFFM	DEG_ODPH_VHL_1	0.1111
p.F31L	DO43154	UCEC	ICGC	LAPRRSPTPFFM	DEG_ODPH_VHL_1	0.6981
p.A20V	SIDM00333	Endometrial Carcinoma	GDSC	LAPRRSPTPFFM	DEG_ODPH_VHL_1	0.0833
p.A20V	ACH-000988	Endometrial/Uterine Cancer	CCLE	LAPRRSPTPFFM	DEG_ODPH_VHL_1	0.0833
p.A20V	MFE-319	endometrium	COSMIC	LAPRRSPTPFFM	DEG_ODPH_VHL_1	0.0833
p.A30V	SIDM01608	Endometrial Carcinoma	GDSC	LAPRRSPTPFFM	DEG_ODPH_VHL_1	0.6936
p.A30V	ACH-000990	Endometrial/Uterine Cancer	CCLE	LAPRRSPTPFFM	DEG_ODPH_VHL_1	0.6936
p.S37P	HMV-II	skin	COSMIC	LAPRRSPTPFFM	DEG_ODPH_VHL_1	0.6752
p.F42S	HMV-II	skin	COSMIC	LAPRRSPTPFFM	DEG_ODPH_VHL_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6P5S7	Ribonuclease kappa	DEG_ODPH_VHL_1	29:40	LAPRRSPTPFFM	VHL	0.8821	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons