DegronMD - Q6P5Z2(PKN3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P493L	TCGA-21-1079	LUSC	TCGA	PKKTPLGE	DEG_SCF_FBW7_2	498:505	Mutation rewiring degron network	0.1944
p.P493L	TCGA-39-5039	LUSC	TCGA	PKKTPLGE	DEG_SCF_FBW7_2	498:505	Mutation rewiring degron network	0.1944
p.P493L	DO26846	LUSC	ICGC	PKKTPLGE	DEG_SCF_FBW7_2	498:505	Mutation rewiring degron network	0.1944
p.P493L	DO26550	LUSC	ICGC	PKKTPLGE	DEG_SCF_FBW7_2	498:505	Mutation rewiring degron network	0.1944
p.M507I	TCGA-55-8205	LUAD	TCGA	PKKTPLGE	DEG_SCF_FBW7_2	498:505	Mutation rewiring degron network	0.2778
p.M507I	DO48884	LUAD	ICGC	PKKTPLGE	DEG_SCF_FBW7_2	498:505	Mutation rewiring degron network	0.2778
p.G504D	TCGA-C5-A1MK	CESC	TCGA	PKKTPLGE	DEG_SCF_FBW7_2	498:505	Mutation altering degron motif	0.6087
p.G504D	DO6290	CESC	ICGC	PKKTPLGE	DEG_SCF_FBW7_2	498:505	Mutation altering degron motif	0.6087
p.P514S	TCGA-EE-A2A1	SKCM	TCGA	PKKTPLGE	DEG_SCF_FBW7_2	498:505	Mutation rewiring degron network	0.0833
p.P514S	DO220906	MELA	ICGC	PKKTPLGE	DEG_SCF_FBW7_2	498:505	Mutation rewiring degron network	0.0833
p.P514S	DO38045	SKCM	ICGC	PKKTPLGE	DEG_SCF_FBW7_2	498:505	Mutation rewiring degron network	0.0833
p.P502S	TCGA-ER-A19D	SKCM	TCGA	PKKTPLGE	DEG_SCF_FBW7_2	498:505	Mutation altering degron motif	0.6752
p.P502S	DO23538	LIRI	ICGC	PKKTPLGE	DEG_SCF_FBW7_2	498:505	Mutation altering degron motif	0.6752
p.P502S	DO37750	SKCM	ICGC	PKKTPLGE	DEG_SCF_FBW7_2	498:505	Mutation altering degron motif	0.6752
p.R515H	TCGA-FI-A2D0	UCEC	TCGA	PKKTPLGE	DEG_SCF_FBW7_2	498:505	Mutation rewiring degron network	0.0556
p.R515H	DO43891	UCEC	ICGC	PKKTPLGE	DEG_SCF_FBW7_2	498:505	Mutation rewiring degron network	0.0556
p.R515C	DO222765	COCA	ICGC	PKKTPLGE	DEG_SCF_FBW7_2	498:505	Mutation rewiring degron network	0.0556
p.R515C	DO233820	GACA	ICGC	PKKTPLGE	DEG_SCF_FBW7_2	498:505	Mutation rewiring degron network	0.0556
p.PP513PS	DO220906	MELA	ICGC	PKKTPLGE	DEG_SCF_FBW7_2	498:505	Mutation rewiring degron network	0
p.D489A	DO229453	SKCA	ICGC	PKKTPLGE	DEG_SCF_FBW7_2	498:505	Mutation rewiring degron network	0.0833
p.P509L	SIDM00797	Melanoma	GDSC	PKKTPLGE	DEG_SCF_FBW7_2	498:505	Mutation rewiring degron network	0.2222
p.P509L	ACH-000788	Skin Cancer	CCLE	PKKTPLGE	DEG_SCF_FBW7_2	498:505	Mutation rewiring degron network	0.2222
p.P509L	A2058	skin	COSMIC	PKKTPLGE	DEG_SCF_FBW7_2	498:505	Mutation rewiring degron network	0.2222

Kaplan plot for PKN3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PKN3

UniProt ID: Q6P5Z2

Entrez ID: 29941

Protein name: Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN-beta) (Protein-kinase C-related kinase 3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PKN3 in