DegronMD

Uniprot ID: Q6P5Z2

Source protein: Serine/threonine-protein kinase N3

Source gene: PKN3

Class: DEG_SCF_FBW7_2

Location: 498:505

E3 ligase: FBXW7

DEGRON score: 0.628

ASA_SCORE: 93.55

COIL: 0.9045

CONS_SCORE: 0.3634

DSS_SCORE: 0.7742

HELIX: 0.0306

FCONS_SCORE: 0.9033

RIG_SCORE: 0.6059

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P493L	TCGA-21-1079	LUSC	TCGA	PKKTPLGE	DEG_SCF_FBW7_2	0.1944
p.P493L	TCGA-39-5039	LUSC	TCGA	PKKTPLGE	DEG_SCF_FBW7_2	0.1944
p.P493L	DO26846	LUSC	ICGC	PKKTPLGE	DEG_SCF_FBW7_2	0.1944
p.P493L	DO26550	LUSC	ICGC	PKKTPLGE	DEG_SCF_FBW7_2	0.1944
p.M507I	TCGA-55-8205	LUAD	TCGA	PKKTPLGE	DEG_SCF_FBW7_2	0.2778
p.M507I	DO48884	LUAD	ICGC	PKKTPLGE	DEG_SCF_FBW7_2	0.2778
p.G504D	TCGA-C5-A1MK	CESC	TCGA	PKKTPLGE	DEG_SCF_FBW7_2	0.6087
p.G504D	DO6290	CESC	ICGC	PKKTPLGE	DEG_SCF_FBW7_2	0.6087
p.P514S	TCGA-EE-A2A1	SKCM	TCGA	PKKTPLGE	DEG_SCF_FBW7_2	0.0833
p.P514S	DO220906	MELA	ICGC	PKKTPLGE	DEG_SCF_FBW7_2	0.0833
p.P514S	DO38045	SKCM	ICGC	PKKTPLGE	DEG_SCF_FBW7_2	0.0833
p.P502S	TCGA-ER-A19D	SKCM	TCGA	PKKTPLGE	DEG_SCF_FBW7_2	0.6752
p.P502S	DO23538	LIRI	ICGC	PKKTPLGE	DEG_SCF_FBW7_2	0.6752
p.P502S	DO37750	SKCM	ICGC	PKKTPLGE	DEG_SCF_FBW7_2	0.6752
p.R515H	TCGA-FI-A2D0	UCEC	TCGA	PKKTPLGE	DEG_SCF_FBW7_2	0.0556
p.R515H	DO43891	UCEC	ICGC	PKKTPLGE	DEG_SCF_FBW7_2	0.0556
p.R515C	DO222765	COCA	ICGC	PKKTPLGE	DEG_SCF_FBW7_2	0.0556
p.R515C	DO233820	GACA	ICGC	PKKTPLGE	DEG_SCF_FBW7_2	0.0556
p.PP513PS	DO220906	MELA	ICGC	PKKTPLGE	DEG_SCF_FBW7_2	0
p.D489A	DO229453	SKCA	ICGC	PKKTPLGE	DEG_SCF_FBW7_2	0.0833
p.P509L	SIDM00797	Melanoma	GDSC	PKKTPLGE	DEG_SCF_FBW7_2	0.2222
p.P509L	ACH-000788	Skin Cancer	CCLE	PKKTPLGE	DEG_SCF_FBW7_2	0.2222
p.P509L	A2058	skin	COSMIC	PKKTPLGE	DEG_SCF_FBW7_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6P5Z2	Serine/threonine-protein kinase N3	DEG_SCF_FBW7_2	498:505	PKKTPLGE	FBXW7	0.628	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons