DegronMD - Q6P9B9(INTS5)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.H318Y	TCGA-90-A4ED	LUSC	TCGA	IRRELLRMF	DEG_APCC_DBOX_1	309:317	Mutation rewiring degron network	0.3056
p.H318Y	DO45482	LUSC	ICGC	IRRELLRMF	DEG_APCC_DBOX_1	309:317	Mutation rewiring degron network	0.3056
p.R315Q	TCGA-AG-A002	READ	TCGA	IRRELLRMF	DEG_APCC_DBOX_1	309:317	Mutation altering degron motif	0.6218
p.R315Q	DO227745	COCA	ICGC	IRRELLRMF	DEG_APCC_DBOX_1	309:317	Mutation altering degron motif	0.6218
p.G326E	TCGA-AP-A0LM	UCEC	TCGA	IRRELLRMF	DEG_APCC_DBOX_1	309:317	Mutation rewiring degron network	0.0833
p.G326E	DO43306	UCEC	ICGC	IRRELLRMF	DEG_APCC_DBOX_1	309:317	Mutation rewiring degron network	0.0833
p.G306V	TCGA-CN-6010	HNSC	TCGA	IRRELLRMF	DEG_APCC_DBOX_1	309:317	Mutation rewiring degron network	0.25
p.G306V	DO14766	HNSC	ICGC	IRRELLRMF	DEG_APCC_DBOX_1	309:317	Mutation rewiring degron network	0.25
p.A322E	DO229009	LICA	ICGC	IRRELLRMF	DEG_APCC_DBOX_1	309:317	Mutation rewiring degron network	0.1944
p.RH304RY	DO222390	MELA	ICGC	IRRELLRMF	DEG_APCC_DBOX_1	309:317	Mutation rewiring degron network	0
p.R310Q	SIDM00946	T-Lymphoblastic Leukemia	GDSC	IRRELLRMF	DEG_APCC_DBOX_1	309:317	Mutation altering degron motif	0.7329
p.R310Q	SIDM00006	Other Solid Cancers	GDSC	IRRELLRMF	DEG_APCC_DBOX_1	309:317	Mutation altering degron motif	0.7329
p.R310Q	ACH-000981	Leukemia	CCLE	IRRELLRMF	DEG_APCC_DBOX_1	309:317	Mutation altering degron motif	0.7329
p.R310Q	ACH-001552	Skin Cancer	CCLE	IRRELLRMF	DEG_APCC_DBOX_1	309:317	Mutation altering degron motif	0.7329
p.R310Q	DND-41	haematopoietic and lymphoid tissue	COSMIC	IRRELLRMF	DEG_APCC_DBOX_1	309:317	Mutation altering degron motif	0.7329
p.R310Q	MCC26	skin	COSMIC	IRRELLRMF	DEG_APCC_DBOX_1	309:317	Mutation altering degron motif	0.7329
p.G327S	ACH-002287	Colon/Colorectal Cancer	CCLE	IRRELLRMF	DEG_APCC_DBOX_1	309:317	Mutation rewiring degron network	0.0556
p.G327S	NCI-H630	large intestine	COSMIC	IRRELLRMF	DEG_APCC_DBOX_1	309:317	Mutation rewiring degron network	0.0556

Kaplan plot for INTS5 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

INTS5

UniProt ID: Q6P9B9

Entrez ID: 80789

Protein name: Integrator complex subunit 5 (Int5)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for INTS5 in