DegronMD

Uniprot ID: Q6P9B9

Source protein: Integrator complex subunit 5

Source gene: INTS5

Class: DEG_APCC_DBOX_1

Location: 309:317

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5941

ASA_SCORE: 53.5444

COIL: 0.0166

CONS_SCORE: 0.4694

DSS_SCORE: 0.3238

HELIX: 0.9831

FCONS_SCORE: 1.1893

RIG_SCORE: 0.8072

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H318Y	TCGA-90-A4ED	LUSC	TCGA	IRRELLRMF	DEG_APCC_DBOX_1	0.3056
p.H318Y	DO45482	LUSC	ICGC	IRRELLRMF	DEG_APCC_DBOX_1	0.3056
p.R315Q	TCGA-AG-A002	READ	TCGA	IRRELLRMF	DEG_APCC_DBOX_1	0.6218
p.R315Q	DO227745	COCA	ICGC	IRRELLRMF	DEG_APCC_DBOX_1	0.6218
p.G326E	TCGA-AP-A0LM	UCEC	TCGA	IRRELLRMF	DEG_APCC_DBOX_1	0.0833
p.G326E	DO43306	UCEC	ICGC	IRRELLRMF	DEG_APCC_DBOX_1	0.0833
p.G306V	TCGA-CN-6010	HNSC	TCGA	IRRELLRMF	DEG_APCC_DBOX_1	0.25
p.G306V	DO14766	HNSC	ICGC	IRRELLRMF	DEG_APCC_DBOX_1	0.25
p.A322E	DO229009	LICA	ICGC	IRRELLRMF	DEG_APCC_DBOX_1	0.1944
p.RH304RY	DO222390	MELA	ICGC	IRRELLRMF	DEG_APCC_DBOX_1	0
p.R310Q	SIDM00946	T-Lymphoblastic Leukemia	GDSC	IRRELLRMF	DEG_APCC_DBOX_1	0.7329
p.R310Q	SIDM00006	Other Solid Cancers	GDSC	IRRELLRMF	DEG_APCC_DBOX_1	0.7329
p.R310Q	ACH-000981	Leukemia	CCLE	IRRELLRMF	DEG_APCC_DBOX_1	0.7329
p.R310Q	ACH-001552	Skin Cancer	CCLE	IRRELLRMF	DEG_APCC_DBOX_1	0.7329
p.R310Q	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	IRRELLRMF	DEG_APCC_DBOX_1	0.7329
p.R310Q	MCC26	skin	COSMIC	IRRELLRMF	DEG_APCC_DBOX_1	0.7329
p.G327S	ACH-002287	Colon/Colorectal Cancer	CCLE	IRRELLRMF	DEG_APCC_DBOX_1	0.0556
p.G327S	NCI-H630	large_intestine	COSMIC	IRRELLRMF	DEG_APCC_DBOX_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6P9B9	Integrator complex subunit 5	DEG_APCC_DBOX_1	309:317	IRRELLRMF	APC,CDC20,FZR1	0.5941	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons