DegronMD - Q6PCD5(RFWD3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V204L	TCGA-64-5775	LUAD	TCGA	VSSSS	DEG_SPOP_SBC_1	210:214	Mutation rewiring degron network	0.1667
p.V204L	DO26025	LUAD	ICGC	VSSSS	DEG_SPOP_SBC_1	210:214	Mutation rewiring degron network	0.1667
p.E59K	TCGA-91-6830	LUAD	TCGA	DVVSSQGVPSI	DEG_COP1_1	42:52	Mutation rewiring degron network	0.1389
p.E59K	DO25867	LUAD	ICGC	DVVSSQGVPSI	DEG_COP1_1	42:52	Mutation rewiring degron network	0.1389
p.P57S	TCGA-A5-A0G1	UCEC	TCGA	DVVSSQGVPSI	DEG_COP1_1	42:52	Mutation rewiring degron network	0.1944
p.P57S	DO42472	UCEC	ICGC	DVVSSQGVPSI	DEG_COP1_1	42:52	Mutation rewiring degron network	0.1944
p.S221F	TCGA-DK-A3IT	BLCA	TCGA	VSSSS	DEG_SPOP_SBC_1	210:214	Mutation rewiring degron network	0.1389
p.S221F	DO779	BLCA	ICGC	VSSSS	DEG_SPOP_SBC_1	210:214	Mutation rewiring degron network	0.1389
p.P50S	TCGA-EE-A2GR	SKCM	TCGA	DVVSSQGVPSI	DEG_COP1_1	42:52	Mutation altering degron motif	0.6752
p.P50S	DO37996	SKCM	ICGC	DVVSSQGVPSI	DEG_COP1_1	42:52	Mutation altering degron motif	0.6752
p.D215N	TCGA-FD-A3SN	BLCA	TCGA	VSSSS	DEG_SPOP_SBC_1	210:214	Mutation rewiring degron network	0.3056
p.D215N	DO490	BLCA	ICGC	VSSSS	DEG_SPOP_SBC_1	210:214	Mutation rewiring degron network	0.3056
p.S216C	TCGA-FD-A43X	BLCA	TCGA	VSSSS	DEG_SPOP_SBC_1	210:214	Mutation rewiring degron network	0.2778
p.S216C	DO44067	BLCA	ICGC	VSSSS	DEG_SPOP_SBC_1	210:214	Mutation rewiring degron network	0.2778
p.D219E	DO229031	LICA	ICGC	VSSSS	DEG_SPOP_SBC_1	210:214	Mutation rewiring degron network	0.1944
p.S220R	DO229045	LICA	ICGC	VSSSS	DEG_SPOP_SBC_1	210:214	Mutation rewiring degron network	0.1667
p.D42E	SIDM00014	Colorectal Carcinoma	GDSC	DVVSSQGVPSI	DEG_COP1_1	42:52	Mutation altering degron motif	0.5647
p.V49L	ACH-001610	Brain Cancer	CCLE	DVVSSQGVPSI	DEG_COP1_1	42:52	Mutation altering degron motif	0.6765
p.V39A	LIM1215	large intestine	COSMIC	DVVSSQGVPSI	DEG_COP1_1	42:52	Mutation rewiring degron network	0.25

Kaplan plot for RFWD3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RFWD3

UniProt ID: Q6PCD5

Entrez ID: 55159

Protein name: E3 ubiquitin-protein ligase RFWD3 (EC 2.3.2.27) (RING finger and WD repeat domain-containing protein 3) (RING finger protein 201)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RFWD3 in