DegronMD

Uniprot ID: Q6PCD5

Source protein: E3 ubiquitin-protein ligase RFWD3

Source gene: RFWD3

Class: DEG_COP1_1

Location: 42:52

E3 ligase: COP1

DEGRON score: 0.9829

ASA_SCORE: 70.4364

COIL: 0.8224

CONS_SCORE: 0.3153

DSS_SCORE: 0.432

HELIX: 0.1066

FCONS_SCORE: 0.9484

RIG_SCORE: 0.6817

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E59K	TCGA-91-6830	LUAD	TCGA	DVVSSQGVPSI	DEG_COP1_1	0.1389
p.E59K	DO25867	LUAD	ICGC	DVVSSQGVPSI	DEG_COP1_1	0.1389
p.P57S	TCGA-A5-A0G1	UCEC	TCGA	DVVSSQGVPSI	DEG_COP1_1	0.1944
p.P57S	DO42472	UCEC	ICGC	DVVSSQGVPSI	DEG_COP1_1	0.1944
p.P50S	TCGA-EE-A2GR	SKCM	TCGA	DVVSSQGVPSI	DEG_COP1_1	0.6752
p.P50S	DO37996	SKCM	ICGC	DVVSSQGVPSI	DEG_COP1_1	0.6752
p.D42E	SIDM00014	Colorectal Carcinoma	GDSC	DVVSSQGVPSI	DEG_COP1_1	0.5647
p.V49L	ACH-001610	Brain Cancer	CCLE	DVVSSQGVPSI	DEG_COP1_1	0.6765
p.V39A	LIM1215	large_intestine	COSMIC	DVVSSQGVPSI	DEG_COP1_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6PCD5	E3 ubiquitin-protein ligase RFWD3	DEG_COP1_1	42:52	DVVSSQGVPSI	COP1	0.9829	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons