DegronMD - Q6PEW0(PRSS54)

PRSS54

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E362G	TCGA-BH-A18G	BRCA	TCGA	SPEASVQPL	DEG_SIAH_1	346:354	Mutation rewiring degron network	0.1111
p.G361W	TCGA-D3-A1QA	SKCM	TCGA	SPEASVQPL	DEG_SIAH_1	346:354	Mutation rewiring degron network	0.1389
p.P347T	TCGA-D3-A3C8	SKCM	TCGA	SPEASVQPL	DEG_SIAH_1	346:354	Mutation altering degron motif	0.7031
p.E348K	TCGA-DK-A1A3	BLCA	TCGA	SPEASVQPL	DEG_SIAH_1	346:354	Mutation altering degron motif	0.591
p.E342K	TCGA-FW-A3R5	SKCM	TCGA	SPEASVQPL	DEG_SIAH_1	346:354	Mutation rewiring degron network	0.2222
p.E342K	TCGA-W3-AA1V	SKCM	TCGA	SPEASVQPL	DEG_SIAH_1	346:354	Mutation rewiring degron network	0.2222
p.D357G	TCGA-HU-A4GT	STAD	TCGA	SPEASVQPL	DEG_SIAH_1	346:354	Mutation rewiring degron network	0.25
p.G360S	SIDM00981	B-Cell Non-Hodgkin's Lymphoma	GDSC	SPEASVQPL	DEG_SIAH_1	346:354	Mutation rewiring degron network	0.1667
p.G360S	DOHH-2	haematopoietic and lymphoid tissue	COSMIC	SPEASVQPL	DEG_SIAH_1	346:354	Mutation rewiring degron network	0.1667
p.G360D	ACH-001649	Prostate Cancer	CCLE	SPEASVQPL	DEG_SIAH_1	346:354	Mutation rewiring degron network	0.1667

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*NOTE: the Kaplan plots were collected from OncoLnc