DegronMD

Uniprot ID: Q6PEW0

Source protein: Inactive serine protease 54

Source gene: PRSS54

Class: DEG_SIAH_1

Location: 346:354

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9684

ASA_SCORE: 60.2556

COIL: 0.7824

CONS_SCORE: 0.463

DSS_SCORE: 0.4523

HELIX: 0.1362

FCONS_SCORE: 0.8856

RIG_SCORE: 0.7133

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E362G	TCGA-BH-A18G	BRCA	TCGA	SPEASVQPL	DEG_SIAH_1	0.1111
p.G361W	TCGA-D3-A1QA	SKCM	TCGA	SPEASVQPL	DEG_SIAH_1	0.1389
p.P347T	TCGA-D3-A3C8	SKCM	TCGA	SPEASVQPL	DEG_SIAH_1	0.7031
p.E348K	TCGA-DK-A1A3	BLCA	TCGA	SPEASVQPL	DEG_SIAH_1	0.591
p.E342K	TCGA-FW-A3R5	SKCM	TCGA	SPEASVQPL	DEG_SIAH_1	0.2222
p.E342K	TCGA-W3-AA1V	SKCM	TCGA	SPEASVQPL	DEG_SIAH_1	0.2222
p.D357G	TCGA-HU-A4GT	STAD	TCGA	SPEASVQPL	DEG_SIAH_1	0.25
p.G360S	SIDM00981	B-Cell Non-Hodgkin's Lymphoma	GDSC	SPEASVQPL	DEG_SIAH_1	0.1667
p.G360S	DOHH-2	haematopoietic_and_lymphoid_tissue	COSMIC	SPEASVQPL	DEG_SIAH_1	0.1667
p.G360D	ACH-001649	Prostate Cancer	CCLE	SPEASVQPL	DEG_SIAH_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6PEW0	Inactive serine protease 54	DEG_SIAH_1	346:354	SPEASVQPL	SIAH1,SIAH2,SIAH3	0.9684	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons