DegronMD - Q6PHW0(IYD)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P266S	TCGA-A5-A0G1	UCEC	TCGA	SKEATVPDL	DEG_COP1_1	269:277	Mutation rewiring degron network	0.25
p.P266S	DO42472	UCEC	ICGC	SKEATVPDL	DEG_COP1_1	269:277	Mutation rewiring degron network	0.25
p.W281C	TCGA-FD-A43U	BLCA	TCGA	SKEATVPDL	DEG_COP1_1	269:277	Mutation rewiring degron network	0.2222
p.W281C	DO645	BLCA	ICGC	SKEATVPDL	DEG_COP1_1	269:277	Mutation rewiring degron network	0.2222
p.G267A	DO224676	BRCA	ICGC	SKEATVPDL	DEG_COP1_1	269:277	Mutation rewiring degron network	0.2778
p.R269K	DO1153	BRCA	ICGC	SKEATVPDL	DEG_COP1_1	269:277	Mutation altering degron motif	0.7237
p.T273M	DO223496	CLLE	ICGC	SKEATVPDL	DEG_COP1_1	269:277	Mutation altering degron motif	0.6312
p.C265Y	DO230334	COCA	ICGC	SKEATVPDL	DEG_COP1_1	269:277	Mutation rewiring degron network	0.2222
p.C265Y	DO229010	COCA	ICGC	SKEATVPDL	DEG_COP1_1	269:277	Mutation rewiring degron network	0.2222
p.C265Y	DO229013	COCA	ICGC	SKEATVPDL	DEG_COP1_1	269:277	Mutation rewiring degron network	0.2222
p.C265Y	DO229016	COCA	ICGC	SKEATVPDL	DEG_COP1_1	269:277	Mutation rewiring degron network	0.2222
p.C265Y	DO229003	COCA	ICGC	SKEATVPDL	DEG_COP1_1	269:277	Mutation rewiring degron network	0.2222
p.C265Y	DO229005	COCA	ICGC	SKEATVPDL	DEG_COP1_1	269:277	Mutation rewiring degron network	0.2222
p.C265Y	DO51038	LAML	ICGC	SKEATVPDL	DEG_COP1_1	269:277	Mutation rewiring degron network	0.2222
p.C265Y	DO228957	LICA	ICGC	SKEATVPDL	DEG_COP1_1	269:277	Mutation rewiring degron network	0.2222
p.C265Y	DO229028	LICA	ICGC	SKEATVPDL	DEG_COP1_1	269:277	Mutation rewiring degron network	0.2222
p.C265Y	DO229047	LICA	ICGC	SKEATVPDL	DEG_COP1_1	269:277	Mutation rewiring degron network	0.2222
p.C265Y	DO52365	LUSC	ICGC	SKEATVPDL	DEG_COP1_1	269:277	Mutation rewiring degron network	0.2222
p.C265R	DO229010	COCA	ICGC	SKEATVPDL	DEG_COP1_1	269:277	Mutation rewiring degron network	0.2222
p.C265R	DO229013	COCA	ICGC	SKEATVPDL	DEG_COP1_1	269:277	Mutation rewiring degron network	0.2222
p.C265R	DO229016	COCA	ICGC	SKEATVPDL	DEG_COP1_1	269:277	Mutation rewiring degron network	0.2222
p.C265R	DO229003	COCA	ICGC	SKEATVPDL	DEG_COP1_1	269:277	Mutation rewiring degron network	0.2222
p.C265R	DO229005	COCA	ICGC	SKEATVPDL	DEG_COP1_1	269:277	Mutation rewiring degron network	0.2222
p.C265R	DO229353	LAML	ICGC	SKEATVPDL	DEG_COP1_1	269:277	Mutation rewiring degron network	0.2222
p.C265R	DO229028	LICA	ICGC	SKEATVPDL	DEG_COP1_1	269:277	Mutation rewiring degron network	0.2222
p.S273N	DO50970	LICA	ICGC	SKEATVPDL	DEG_COP1_1	269:277	Mutation altering degron motif	0.7069
p.S269R	DO45321	LUAD	ICGC	SKEATVPDL	DEG_COP1_1	269:277	Mutation altering degron motif	0.7427
p.P264L	DO222418	MELA	ICGC	SKEATVPDL	DEG_COP1_1	269:277	Mutation rewiring degron network	0.1944
p.P264L	DO37655	SKCM	ICGC	SKEATVPDL	DEG_COP1_1	269:277	Mutation rewiring degron network	0.1944
p.D276N	DO47368	SKCM	ICGC	SKEATVPDL	DEG_COP1_1	269:277	Mutation altering degron motif	0.6932

Kaplan plot for IYD in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

IYD

UniProt ID: Q6PHW0

Entrez ID: 389434

Protein name: Iodotyrosine deiodinase 1 (IYD-1) (EC 1.21.1.1) (Iodotyrosine dehalogenase 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for IYD in