DegronMD

Uniprot ID: Q6PHW0

Source protein: Iodotyrosine deiodinase 1

Source gene: IYD

Class: DEG_COP1_1

Location: 269:277

E3 ligase: COP1

DEGRON score: 0.7496

ASA_SCORE: 88.3778

COIL: 0.939

CONS_SCORE: 0.5523

DSS_SCORE: 0.3228

HELIX: 0.0257

FCONS_SCORE: 0.8947

RIG_SCORE: 0.7604

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P266S	TCGA-A5-A0G1	UCEC	TCGA	SKEATVPDL	DEG_COP1_1	0.25
p.P266S	DO42472	UCEC	ICGC	SKEATVPDL	DEG_COP1_1	0.25
p.W281C	TCGA-FD-A43U	BLCA	TCGA	SKEATVPDL	DEG_COP1_1	0.2222
p.W281C	DO645	BLCA	ICGC	SKEATVPDL	DEG_COP1_1	0.2222
p.G267A	DO224676	BRCA	ICGC	SKEATVPDL	DEG_COP1_1	0.2778
p.R269K	DO1153	BRCA	ICGC	SKEATVPDL	DEG_COP1_1	0.7237
p.T273M	DO223496	CLLE	ICGC	SKEATVPDL	DEG_COP1_1	0.6312
p.C265Y	DO230334	COCA	ICGC	SKEATVPDL	DEG_COP1_1	0.2222
p.C265Y	DO229010	COCA	ICGC	SKEATVPDL	DEG_COP1_1	0.2222
p.C265Y	DO229013	COCA	ICGC	SKEATVPDL	DEG_COP1_1	0.2222
p.C265Y	DO229016	COCA	ICGC	SKEATVPDL	DEG_COP1_1	0.2222
p.C265Y	DO229003	COCA	ICGC	SKEATVPDL	DEG_COP1_1	0.2222
p.C265Y	DO229005	COCA	ICGC	SKEATVPDL	DEG_COP1_1	0.2222
p.C265Y	DO51038	LAML	ICGC	SKEATVPDL	DEG_COP1_1	0.2222
p.C265Y	DO228957	LICA	ICGC	SKEATVPDL	DEG_COP1_1	0.2222
p.C265Y	DO229028	LICA	ICGC	SKEATVPDL	DEG_COP1_1	0.2222
p.C265Y	DO229047	LICA	ICGC	SKEATVPDL	DEG_COP1_1	0.2222
p.C265Y	DO52365	LUSC	ICGC	SKEATVPDL	DEG_COP1_1	0.2222
p.C265R	DO229010	COCA	ICGC	SKEATVPDL	DEG_COP1_1	0.2222
p.C265R	DO229013	COCA	ICGC	SKEATVPDL	DEG_COP1_1	0.2222
p.C265R	DO229016	COCA	ICGC	SKEATVPDL	DEG_COP1_1	0.2222
p.C265R	DO229003	COCA	ICGC	SKEATVPDL	DEG_COP1_1	0.2222
p.C265R	DO229005	COCA	ICGC	SKEATVPDL	DEG_COP1_1	0.2222
p.C265R	DO229353	LAML	ICGC	SKEATVPDL	DEG_COP1_1	0.2222
p.C265R	DO229028	LICA	ICGC	SKEATVPDL	DEG_COP1_1	0.2222
p.S273N	DO50970	LICA	ICGC	SKEATVPDL	DEG_COP1_1	0.7069
p.S269R	DO45321	LUAD	ICGC	SKEATVPDL	DEG_COP1_1	0.7427
p.P264L	DO222418	MELA	ICGC	SKEATVPDL	DEG_COP1_1	0.1944
p.P264L	DO37655	SKCM	ICGC	SKEATVPDL	DEG_COP1_1	0.1944
p.D276N	DO47368	SKCM	ICGC	SKEATVPDL	DEG_COP1_1	0.6932

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6PHW0	Iodotyrosine deiodinase 1	DEG_COP1_1	269:277	SKEATVPDL	COP1	0.7496	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SKEATVPDL

Degron related mutations and impact score

Drug responses associated with IYD mutations

All proteins holding degron of SKEATVPDL