DegronMD - Q6PIJ6(FBXO38)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D869V	TCGA-49-4505	LUAD	TCGA	ARSRLSHVL	DEG_APCC_DBOX_1	871:879	Mutation rewiring degron network	0.2778
p.K872E	TCGA-AX-A0J0	UCEC	TCGA	ARSRLSHVL	DEG_APCC_DBOX_1	871:879	Mutation altering degron motif	0.7022
p.K872N	TCGA-AX-A2HC	UCEC	TCGA	ARSRLSHVL	DEG_APCC_DBOX_1	871:879	Mutation altering degron motif	0.6918
p.V866A	TCGA-GS-A9TV	DLBC	TCGA	ARSRLSHVL	DEG_APCC_DBOX_1	871:879	Mutation rewiring degron network	0.1944
p.I862F	TCGA-ZS-A9CF	LIHC	TCGA	ARSRLSHVL	DEG_APCC_DBOX_1	871:879	Mutation rewiring degron network	0.0833
p.L868I	DO11196	GBM	ICGC	ARSRLSHVL	DEG_APCC_DBOX_1	871:879	Mutation rewiring degron network	0.25
p.V878L	DO229032	LICA	ICGC	ARSRLSHVL	DEG_APCC_DBOX_1	871:879	Mutation altering degron motif	0.5654
p.R865Q	DO228255	MALY	ICGC	ARSRLSHVL	DEG_APCC_DBOX_1	871:879	Mutation rewiring degron network	0.1667
p.S876F	DO222702	MELA	ICGC	ARSRLSHVL	DEG_APCC_DBOX_1	871:879	Mutation altering degron motif	0.7982
p.E885Q	DO31869	OV	ICGC	ARSRLSHVL	DEG_APCC_DBOX_1	871:879	Mutation rewiring degron network	0.1667
p.R872S	DO47491	SKCM	ICGC	ARSRLSHVL	DEG_APCC_DBOX_1	871:879	Mutation altering degron motif	0.7427
p.E861G	DO42280	UCEC	ICGC	ARSRLSHVL	DEG_APCC_DBOX_1	871:879	Mutation rewiring degron network	0.0556
p.A871T	DO41590	UCEC	ICGC	ARSRLSHVL	DEG_APCC_DBOX_1	871:879	Mutation altering degron motif	0.6028
p.R865W	DO42665	UCEC	ICGC	ARSRLSHVL	DEG_APCC_DBOX_1	871:879	Mutation rewiring degron network	0.1667
p.R865W	SIDM00118	Colorectal Carcinoma	GDSC	ARSRLSHVL	DEG_APCC_DBOX_1	871:879	Mutation rewiring degron network	0.1667
p.R865W	ACH-001081	Colon/Colorectal Cancer	CCLE	ARSRLSHVL	DEG_APCC_DBOX_1	871:879	Mutation rewiring degron network	0.1667
p.R865W	HCC2998	large intestine	COSMIC	ARSRLSHVL	DEG_APCC_DBOX_1	871:879	Mutation rewiring degron network	0.1667
p.L879P	SIDM00845	Burkitt's Lymphoma	GDSC	ARSRLSHVL	DEG_APCC_DBOX_1	871:879	Mutation altering degron motif	0.6471
p.L879P	SIDM00461	Acute Myeloid Leukemia	GDSC	ARSRLSHVL	DEG_APCC_DBOX_1	871:879	Mutation altering degron motif	0.6471
p.L879P	SIDM00946	T-Lymphoblastic Leukemia	GDSC	ARSRLSHVL	DEG_APCC_DBOX_1	871:879	Mutation altering degron motif	0.6471
p.L879P	ACH-000786	Lymphoma	CCLE	ARSRLSHVL	DEG_APCC_DBOX_1	871:879	Mutation altering degron motif	0.6471
p.L879P	ACH-000981	Leukemia	CCLE	ARSRLSHVL	DEG_APCC_DBOX_1	871:879	Mutation altering degron motif	0.6471
p.L879P	ACH-000992	Head and Neck Cancer	CCLE	ARSRLSHVL	DEG_APCC_DBOX_1	871:879	Mutation altering degron motif	0.6471
p.L879P	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	ARSRLSHVL	DEG_APCC_DBOX_1	871:879	Mutation altering degron motif	0.6471
p.L879P	DND-41	haematopoietic and lymphoid tissue	COSMIC	ARSRLSHVL	DEG_APCC_DBOX_1	871:879	Mutation altering degron motif	0.6471
p.L879P	Daudi	haematopoietic and lymphoid tissue	COSMIC	ARSRLSHVL	DEG_APCC_DBOX_1	871:879	Mutation altering degron motif	0.6471
p.V881I	SIDM00845	Burkitt's Lymphoma	GDSC	ARSRLSHVL	DEG_APCC_DBOX_1	871:879	Mutation rewiring degron network	0.2778
p.V881I	SIDM00461	Acute Myeloid Leukemia	GDSC	ARSRLSHVL	DEG_APCC_DBOX_1	871:879	Mutation rewiring degron network	0.2778
p.V881I	SIDM00946	T-Lymphoblastic Leukemia	GDSC	ARSRLSHVL	DEG_APCC_DBOX_1	871:879	Mutation rewiring degron network	0.2778
p.V881I	ACH-000786	Lymphoma	CCLE	ARSRLSHVL	DEG_APCC_DBOX_1	871:879	Mutation rewiring degron network	0.2778
p.V881I	ACH-000992	Head and Neck Cancer	CCLE	ARSRLSHVL	DEG_APCC_DBOX_1	871:879	Mutation rewiring degron network	0.2778
p.V881I	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	ARSRLSHVL	DEG_APCC_DBOX_1	871:879	Mutation rewiring degron network	0.2778
p.V881I	DND-41	haematopoietic and lymphoid tissue	COSMIC	ARSRLSHVL	DEG_APCC_DBOX_1	871:879	Mutation rewiring degron network	0.2778
p.V881I	Daudi	haematopoietic and lymphoid tissue	COSMIC	ARSRLSHVL	DEG_APCC_DBOX_1	871:879	Mutation rewiring degron network	0.2778
p.S885R	HCT-15	large intestine	COSMIC	ARSRLSHVL	DEG_APCC_DBOX_1	871:879	Mutation rewiring degron network	0.1667
p.R864K	EM-2	haematopoietic and lymphoid tissue	COSMIC	ARSRLSHVL	DEG_APCC_DBOX_1	871:879	Mutation rewiring degron network	0.1389
p.T879A	MFE-319	endometrium	COSMIC	ARSRLSHVL	DEG_APCC_DBOX_1	871:879	Mutation altering degron motif	0.7139
p.K888N	CTV-1	haematopoietic and lymphoid tissue	COSMIC	ARSRLSHVL	DEG_APCC_DBOX_1	871:879	Mutation substituting flanking lysine	0.1944

Kaplan plot for FBXO38 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FBXO38

UniProt ID: Q6PIJ6

Entrez ID: 81545

Protein name: F-box only protein 38

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FBXO38 in