DegronMD

Uniprot ID: Q6PIJ6

Source protein: F-box only protein 38

Source gene: FBXO38

Class: DEG_APCC_DBOX_1

Location: 871:879

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9906

ASA_SCORE: 105.1111

COIL: 0.7642

CONS_SCORE: 0.6063

DSS_SCORE: 0.4798

HELIX: 0.22

FCONS_SCORE: 1.1565

RIG_SCORE: 0.7185

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S876F	DO222702	MELA	ICGC	ARSRLSHVL	DEG_APCC_DBOX_1	0.7982
p.R872S	DO47491	SKCM	ICGC	ARSRLSHVL	DEG_APCC_DBOX_1	0.7427
p.T879A	MFE-319	endometrium	COSMIC	ARSRLSHVL	DEG_APCC_DBOX_1	0.7139
p.K872E	TCGA-AX-A0J0	UCEC	TCGA	ARSRLSHVL	DEG_APCC_DBOX_1	0.7022
p.K872N	TCGA-AX-A2HC	UCEC	TCGA	ARSRLSHVL	DEG_APCC_DBOX_1	0.6918
p.L879P	SIDM00845	Burkitt's Lymphoma	GDSC	ARSRLSHVL	DEG_APCC_DBOX_1	0.6471
p.L879P	SIDM00461	Acute Myeloid Leukemia	GDSC	ARSRLSHVL	DEG_APCC_DBOX_1	0.6471
p.L879P	SIDM00946	T-Lymphoblastic Leukemia	GDSC	ARSRLSHVL	DEG_APCC_DBOX_1	0.6471
p.L879P	ACH-000786	Lymphoma	CCLE	ARSRLSHVL	DEG_APCC_DBOX_1	0.6471
p.L879P	ACH-000981	Leukemia	CCLE	ARSRLSHVL	DEG_APCC_DBOX_1	0.6471
p.L879P	ACH-000992	Head and Neck Cancer	CCLE	ARSRLSHVL	DEG_APCC_DBOX_1	0.6471
p.L879P	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	ARSRLSHVL	DEG_APCC_DBOX_1	0.6471
p.L879P	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	ARSRLSHVL	DEG_APCC_DBOX_1	0.6471
p.L879P	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	ARSRLSHVL	DEG_APCC_DBOX_1	0.6471
p.A871T	DO41590	UCEC	ICGC	ARSRLSHVL	DEG_APCC_DBOX_1	0.6028
p.V878L	DO229032	LICA	ICGC	ARSRLSHVL	DEG_APCC_DBOX_1	0.5654
p.D869V	TCGA-49-4505	LUAD	TCGA	ARSRLSHVL	DEG_APCC_DBOX_1	0.2778
p.V881I	SIDM00845	Burkitt's Lymphoma	GDSC	ARSRLSHVL	DEG_APCC_DBOX_1	0.2778
p.V881I	SIDM00461	Acute Myeloid Leukemia	GDSC	ARSRLSHVL	DEG_APCC_DBOX_1	0.2778
p.V881I	SIDM00946	T-Lymphoblastic Leukemia	GDSC	ARSRLSHVL	DEG_APCC_DBOX_1	0.2778
p.V881I	ACH-000786	Lymphoma	CCLE	ARSRLSHVL	DEG_APCC_DBOX_1	0.2778
p.V881I	ACH-000992	Head and Neck Cancer	CCLE	ARSRLSHVL	DEG_APCC_DBOX_1	0.2778
p.V881I	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	ARSRLSHVL	DEG_APCC_DBOX_1	0.2778
p.V881I	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	ARSRLSHVL	DEG_APCC_DBOX_1	0.2778
p.V881I	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	ARSRLSHVL	DEG_APCC_DBOX_1	0.2778

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Drug responses associated with FBXO38 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of ARSRLSHVL

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6PIJ6	F-box only protein 38	DEG_APCC_DBOX_1	871:879	ARSRLSHVL	APC,CDC20,FZR1	0.9906	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ARSRLSHVL

Degron related mutations and impact score

Drug responses associated with FBXO38 mutations

All proteins holding degron of ARSRLSHVL