DegronMD

Uniprot ID: Q6PIJ6

Source protein: F-box only protein 38

Source gene: FBXO38

Class: DEG_APCC_DBOX_1

Location: 871:879

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9906

ASA_SCORE: 105.1111

COIL: 0.7642

CONS_SCORE: 0.6063

DSS_SCORE: 0.4798

HELIX: 0.22

FCONS_SCORE: 1.1565

RIG_SCORE: 0.7185

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D869V	TCGA-49-4505	LUAD	TCGA	ARSRLSHVL	DEG_APCC_DBOX_1	0.2778
p.K872E	TCGA-AX-A0J0	UCEC	TCGA	ARSRLSHVL	DEG_APCC_DBOX_1	0.7022
p.K872N	TCGA-AX-A2HC	UCEC	TCGA	ARSRLSHVL	DEG_APCC_DBOX_1	0.6918
p.V866A	TCGA-GS-A9TV	DLBC	TCGA	ARSRLSHVL	DEG_APCC_DBOX_1	0.1944
p.I862F	TCGA-ZS-A9CF	LIHC	TCGA	ARSRLSHVL	DEG_APCC_DBOX_1	0.0833
p.L868I	DO11196	GBM	ICGC	ARSRLSHVL	DEG_APCC_DBOX_1	0.25
p.V878L	DO229032	LICA	ICGC	ARSRLSHVL	DEG_APCC_DBOX_1	0.5654
p.R865Q	DO228255	MALY	ICGC	ARSRLSHVL	DEG_APCC_DBOX_1	0.1667
p.S876F	DO222702	MELA	ICGC	ARSRLSHVL	DEG_APCC_DBOX_1	0.7982
p.E885Q	DO31869	OV	ICGC	ARSRLSHVL	DEG_APCC_DBOX_1	0.1667
p.R872S	DO47491	SKCM	ICGC	ARSRLSHVL	DEG_APCC_DBOX_1	0.7427
p.E861G	DO42280	UCEC	ICGC	ARSRLSHVL	DEG_APCC_DBOX_1	0.0556
p.A871T	DO41590	UCEC	ICGC	ARSRLSHVL	DEG_APCC_DBOX_1	0.6028
p.R865W	DO42665	UCEC	ICGC	ARSRLSHVL	DEG_APCC_DBOX_1	0.1667
p.R865W	SIDM00118	Colorectal Carcinoma	GDSC	ARSRLSHVL	DEG_APCC_DBOX_1	0.1667
p.R865W	ACH-001081	Colon/Colorectal Cancer	CCLE	ARSRLSHVL	DEG_APCC_DBOX_1	0.1667
p.R865W	HCC2998	large_intestine	COSMIC	ARSRLSHVL	DEG_APCC_DBOX_1	0.1667
p.L879P	SIDM00845	Burkitt's Lymphoma	GDSC	ARSRLSHVL	DEG_APCC_DBOX_1	0.6471
p.L879P	SIDM00461	Acute Myeloid Leukemia	GDSC	ARSRLSHVL	DEG_APCC_DBOX_1	0.6471
p.L879P	SIDM00946	T-Lymphoblastic Leukemia	GDSC	ARSRLSHVL	DEG_APCC_DBOX_1	0.6471
p.L879P	ACH-000786	Lymphoma	CCLE	ARSRLSHVL	DEG_APCC_DBOX_1	0.6471
p.L879P	ACH-000981	Leukemia	CCLE	ARSRLSHVL	DEG_APCC_DBOX_1	0.6471
p.L879P	ACH-000992	Head and Neck Cancer	CCLE	ARSRLSHVL	DEG_APCC_DBOX_1	0.6471
p.L879P	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	ARSRLSHVL	DEG_APCC_DBOX_1	0.6471
p.L879P	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	ARSRLSHVL	DEG_APCC_DBOX_1	0.6471
p.L879P	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	ARSRLSHVL	DEG_APCC_DBOX_1	0.6471
p.V881I	SIDM00845	Burkitt's Lymphoma	GDSC	ARSRLSHVL	DEG_APCC_DBOX_1	0.2778
p.V881I	SIDM00461	Acute Myeloid Leukemia	GDSC	ARSRLSHVL	DEG_APCC_DBOX_1	0.2778
p.V881I	SIDM00946	T-Lymphoblastic Leukemia	GDSC	ARSRLSHVL	DEG_APCC_DBOX_1	0.2778
p.V881I	ACH-000786	Lymphoma	CCLE	ARSRLSHVL	DEG_APCC_DBOX_1	0.2778
p.V881I	ACH-000992	Head and Neck Cancer	CCLE	ARSRLSHVL	DEG_APCC_DBOX_1	0.2778
p.V881I	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	ARSRLSHVL	DEG_APCC_DBOX_1	0.2778
p.V881I	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	ARSRLSHVL	DEG_APCC_DBOX_1	0.2778
p.V881I	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	ARSRLSHVL	DEG_APCC_DBOX_1	0.2778
p.S885R	HCT-15	large_intestine	COSMIC	ARSRLSHVL	DEG_APCC_DBOX_1	0.1667
p.R864K	EM-2	haematopoietic_and_lymphoid_tissue	COSMIC	ARSRLSHVL	DEG_APCC_DBOX_1	0.1389
p.T879A	MFE-319	endometrium	COSMIC	ARSRLSHVL	DEG_APCC_DBOX_1	0.7139
p.K888N	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	ARSRLSHVL	DEG_APCC_DBOX_1	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ARSRLSHVL

Degron related mutations and impact score

Drug responses associated with FBXO38 mutations

All proteins holding degron of ARSRLSHVL

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6PIJ6	F-box only protein 38	DEG_APCC_DBOX_1	871:879	ARSRLSHVL	APC,CDC20,FZR1	0.9906	More...