DegronMD - Q6PIV2(FOXR1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R247Q	TCGA-BK-A139	UCEC	TCGA	PRSCLWKLT	DEG_APCC_DBOX_1	246:254	Mutation altering degron motif	0.7329
p.R247Q	DO41716	UCEC	ICGC	PRSCLWKLT	DEG_APCC_DBOX_1	246:254	Mutation altering degron motif	0.7329
p.R247Q	SIDM00082	Melanoma	GDSC	PRSCLWKLT	DEG_APCC_DBOX_1	246:254	Mutation altering degron motif	0.7329
p.R247Q	ACH-001190	Skin Cancer	CCLE	PRSCLWKLT	DEG_APCC_DBOX_1	246:254	Mutation altering degron motif	0.7329
p.R247Q	SK-MEL-2	skin	COSMIC	PRSCLWKLT	DEG_APCC_DBOX_1	246:254	Mutation altering degron motif	0.7329
p.R259S	TCGA-ER-A19B	SKCM	TCGA	PRSCLWKLT	DEG_APCC_DBOX_1	246:254	Mutation rewiring degron network	0.1944
p.R259S	DO47491	SKCM	ICGC	PRSCLWKLT	DEG_APCC_DBOX_1	246:254	Mutation rewiring degron network	0.1944
p.R260C	TCGA-F7-A622	HNSC	TCGA	PRSCLWKLT	DEG_APCC_DBOX_1	246:254	Mutation rewiring degron network	0.1667
p.R260C	DO49039	HNSC	ICGC	PRSCLWKLT	DEG_APCC_DBOX_1	246:254	Mutation rewiring degron network	0.1667
p.G241R	DO227976	COCA	ICGC	PRSCLWKLT	DEG_APCC_DBOX_1	246:254	Mutation rewiring degron network	0.1944
p.S243N	DO233088	GACA	ICGC	PRSCLWKLT	DEG_APCC_DBOX_1	246:254	Mutation rewiring degron network	0.25
p.R260H	DO233884	GACA	ICGC	PRSCLWKLT	DEG_APCC_DBOX_1	246:254	Mutation rewiring degron network	0.1667
p.R260H	SIDM00910	Neuroblastoma	GDSC	PRSCLWKLT	DEG_APCC_DBOX_1	246:254	Mutation rewiring degron network	0.1667
p.R260H	ACH-000120	Neuroblastoma	CCLE	PRSCLWKLT	DEG_APCC_DBOX_1	246:254	Mutation rewiring degron network	0.1667
p.R260H	CHP-212	autonomic ganglia	COSMIC	PRSCLWKLT	DEG_APCC_DBOX_1	246:254	Mutation rewiring degron network	0.1667
p.A262V	SIDM00656	Burkitt's Lymphoma	GDSC	PRSCLWKLT	DEG_APCC_DBOX_1	246:254	Mutation rewiring degron network	0.1111
p.A262V	SIDM00641	Burkitt's Lymphoma	GDSC	PRSCLWKLT	DEG_APCC_DBOX_1	246:254	Mutation rewiring degron network	0.1111
p.H258P	ACH-000061	Lymphoma	CCLE	PRSCLWKLT	DEG_APCC_DBOX_1	246:254	Mutation rewiring degron network	0.2222
p.R245W	ACH-000856	Breast Cancer	CCLE	PRSCLWKLT	DEG_APCC_DBOX_1	246:254	Mutation rewiring degron network	0.3056

Kaplan plot for FOXR1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FOXR1

UniProt ID: Q6PIV2

Entrez ID: 283150

Protein name: Forkhead box protein R1 (Forkhead box protein N5)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FOXR1 in