DegronMD

Uniprot ID: Q6PIV2

Source protein: Forkhead box protein R1

Source gene: FOXR1

Class: DEG_APCC_DBOX_1

Location: 246:254

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.904

ASA_SCORE: 46.7778

COIL: 0.6647

CONS_SCORE: 0.7497

DSS_SCORE: 0.3975

HELIX: 0.0742

FCONS_SCORE: 1.3778

RIG_SCORE: 0.7895

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R247Q	TCGA-BK-A139	UCEC	TCGA	PRSCLWKLT	DEG_APCC_DBOX_1	0.7329
p.R247Q	DO41716	UCEC	ICGC	PRSCLWKLT	DEG_APCC_DBOX_1	0.7329
p.R247Q	SIDM00082	Melanoma	GDSC	PRSCLWKLT	DEG_APCC_DBOX_1	0.7329
p.R247Q	ACH-001190	Skin Cancer	CCLE	PRSCLWKLT	DEG_APCC_DBOX_1	0.7329
p.R247Q	SK-MEL-2	skin	COSMIC	PRSCLWKLT	DEG_APCC_DBOX_1	0.7329
p.R259S	TCGA-ER-A19B	SKCM	TCGA	PRSCLWKLT	DEG_APCC_DBOX_1	0.1944
p.R259S	DO47491	SKCM	ICGC	PRSCLWKLT	DEG_APCC_DBOX_1	0.1944
p.R260C	TCGA-F7-A622	HNSC	TCGA	PRSCLWKLT	DEG_APCC_DBOX_1	0.1667
p.R260C	DO49039	HNSC	ICGC	PRSCLWKLT	DEG_APCC_DBOX_1	0.1667
p.G241R	DO227976	COCA	ICGC	PRSCLWKLT	DEG_APCC_DBOX_1	0.1944
p.S243N	DO233088	GACA	ICGC	PRSCLWKLT	DEG_APCC_DBOX_1	0.25
p.R260H	DO233884	GACA	ICGC	PRSCLWKLT	DEG_APCC_DBOX_1	0.1667
p.R260H	SIDM00910	Neuroblastoma	GDSC	PRSCLWKLT	DEG_APCC_DBOX_1	0.1667
p.R260H	ACH-000120	Neuroblastoma	CCLE	PRSCLWKLT	DEG_APCC_DBOX_1	0.1667
p.R260H	CHP-212	autonomic_ganglia	COSMIC	PRSCLWKLT	DEG_APCC_DBOX_1	0.1667
p.A262V	SIDM00656	Burkitt's Lymphoma	GDSC	PRSCLWKLT	DEG_APCC_DBOX_1	0.1111
p.A262V	SIDM00641	Burkitt's Lymphoma	GDSC	PRSCLWKLT	DEG_APCC_DBOX_1	0.1111
p.H258P	ACH-000061	Lymphoma	CCLE	PRSCLWKLT	DEG_APCC_DBOX_1	0.2222
p.R245W	ACH-000856	Breast Cancer	CCLE	PRSCLWKLT	DEG_APCC_DBOX_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6PIV2	Forkhead box protein R1	DEG_APCC_DBOX_1	246:254	PRSCLWKLT	APC,CDC20,FZR1	0.904	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons