DegronMD - Q6PL45(BRICD5)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P227Q	TCGA-D3-A2JD	SKCM	TCGA	RRQRLIYLC	DEG_APCC_DBOX_1	232:240	Mutation rewiring degron network	0.1944
p.P227Q	TCGA-EE-A3AH	SKCM	TCGA	RRQRLIYLC	DEG_APCC_DBOX_1	232:240	Mutation rewiring degron network	0.1944
p.P227Q	DO222635	MELA	ICGC	RRQRLIYLC	DEG_APCC_DBOX_1	232:240	Mutation rewiring degron network	0.1944
p.P227Q	DO37543	SKCM	ICGC	RRQRLIYLC	DEG_APCC_DBOX_1	232:240	Mutation rewiring degron network	0.1944
p.P227Q	DO37443	SKCM	ICGC	RRQRLIYLC	DEG_APCC_DBOX_1	232:240	Mutation rewiring degron network	0.1944
p.E222D	DO219094	HNSC	ICGC	RRQRLIYLC	DEG_APCC_DBOX_1	232:240	Mutation rewiring degron network	0.0556
p.E222D	KS-1	central nervous system	COSMIC	RRQRLIYLC	DEG_APCC_DBOX_1	232:240	Mutation rewiring degron network	0.0556
p.L226F	DO228945	LICA	ICGC	RRQRLIYLC	DEG_APCC_DBOX_1	232:240	Mutation rewiring degron network	0.1667
p.T229K	DO229022	LICA	ICGC	RRQRLIYLC	DEG_APCC_DBOX_1	232:240	Mutation rewiring degron network	0.25
p.G225S	DO27287	LUSC	ICGC	RRQRLIYLC	DEG_APCC_DBOX_1	232:240	Mutation rewiring degron network	0.1389
p.G225D	DO48665	SKCM	ICGC	RRQRLIYLC	DEG_APCC_DBOX_1	232:240	Mutation rewiring degron network	0.1389
p.A228V	DO42608	UCEC	ICGC	RRQRLIYLC	DEG_APCC_DBOX_1	232:240	Mutation rewiring degron network	0.2222
p.G230W	CAL-51	breast	COSMIC	RRQRLIYLC	DEG_APCC_DBOX_1	232:240	Mutation rewiring degron network	0.2778

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons