DegronMD

Uniprot ID: Q6PL45

Source protein: BRICHOS domain-containing protein 5

Source gene: BRICD5

Class: DEG_APCC_DBOX_1

Location: 232:240

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5937

ASA_SCORE: 49.7556

COIL: 0.383

CONS_SCORE: 0.8808

DSS_SCORE: 0.0104

HELIX: 0.0751

FCONS_SCORE: 1.3223

RIG_SCORE: 0.9651

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P227Q	TCGA-D3-A2JD	SKCM	TCGA	RRQRLIYLC	DEG_APCC_DBOX_1	0.1944
p.P227Q	TCGA-EE-A3AH	SKCM	TCGA	RRQRLIYLC	DEG_APCC_DBOX_1	0.1944
p.P227Q	DO222635	MELA	ICGC	RRQRLIYLC	DEG_APCC_DBOX_1	0.1944
p.P227Q	DO37543	SKCM	ICGC	RRQRLIYLC	DEG_APCC_DBOX_1	0.1944
p.P227Q	DO37443	SKCM	ICGC	RRQRLIYLC	DEG_APCC_DBOX_1	0.1944
p.E222D	DO219094	HNSC	ICGC	RRQRLIYLC	DEG_APCC_DBOX_1	0.0556
p.E222D	KS-1	central_nervous_system	COSMIC	RRQRLIYLC	DEG_APCC_DBOX_1	0.0556
p.L226F	DO228945	LICA	ICGC	RRQRLIYLC	DEG_APCC_DBOX_1	0.1667
p.T229K	DO229022	LICA	ICGC	RRQRLIYLC	DEG_APCC_DBOX_1	0.25
p.G225S	DO27287	LUSC	ICGC	RRQRLIYLC	DEG_APCC_DBOX_1	0.1389
p.G225D	DO48665	SKCM	ICGC	RRQRLIYLC	DEG_APCC_DBOX_1	0.1389
p.A228V	DO42608	UCEC	ICGC	RRQRLIYLC	DEG_APCC_DBOX_1	0.2222
p.G230W	CAL-51	breast	COSMIC	RRQRLIYLC	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6PL45	BRICHOS domain-containing protein 5	DEG_APCC_DBOX_1	232:240	RRQRLIYLC	APC,CDC20,FZR1	0.5937	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons