DegronMD - Q6QEF8(CORO6)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L362M	TCGA-AP-A1E0	UCEC	TCGA	PDTPGPE	DEG_SCF_FBW7_2	364:370	Mutation rewiring degron network	0.2778
p.L362M	DO43154	UCEC	ICGC	PDTPGPE	DEG_SCF_FBW7_2	364:370	Mutation rewiring degron network	0.2778
p.Q359P	TCGA-BK-A6W3	UCEC	TCGA	PDTPGPE	DEG_SCF_FBW7_2	364:370	Mutation rewiring degron network	0.1944
p.Q359P	DO50076	UCEC	ICGC	PDTPGPE	DEG_SCF_FBW7_2	364:370	Mutation rewiring degron network	0.1944
p.D356H	TCGA-CR-6480	HNSC	TCGA	PDTPGPE	DEG_SCF_FBW7_2	364:370	Mutation rewiring degron network	0.1111
p.D356H	DO14296	HNSC	ICGC	PDTPGPE	DEG_SCF_FBW7_2	364:370	Mutation rewiring degron network	0.1111
p.D365N	TCGA-DK-A2I4	BLCA	TCGA	PDTPGPE	DEG_SCF_FBW7_2	364:370	Mutation altering degron motif	0.5821
p.D365N	DO465	BLCA	ICGC	PDTPGPE	DEG_SCF_FBW7_2	364:370	Mutation altering degron motif	0.5821
p.P367S	TCGA-FW-A3R5	SKCM	TCGA	PDTPGPE	DEG_SCF_FBW7_2	364:370	Mutation altering degron motif	0.6752
p.P367S	DO37406	SKCM	ICGC	PDTPGPE	DEG_SCF_FBW7_2	364:370	Mutation altering degron motif	0.6752
p.P364T	DO229028	LICA	ICGC	PDTPGPE	DEG_SCF_FBW7_2	364:370	Mutation altering degron motif	0.7031
p.P364Q	DO229041	LICA	ICGC	PDTPGPE	DEG_SCF_FBW7_2	364:370	Mutation altering degron motif	0.7035
p.F358L	SIDM01093	Cervical Carcinoma	GDSC	PDTPGPE	DEG_SCF_FBW7_2	364:370	Mutation rewiring degron network	0.1667
p.F358L	SiHa	cervix	COSMIC	PDTPGPE	DEG_SCF_FBW7_2	364:370	Mutation rewiring degron network	0.1667
p.E374Q	SIDM00963	Breast Carcinoma	GDSC	PDTPGPE	DEG_SCF_FBW7_2	364:370	Mutation rewiring degron network	0.2222
p.E374Q	BT-474	breast	COSMIC	PDTPGPE	DEG_SCF_FBW7_2	364:370	Mutation rewiring degron network	0.2222
p.G354D	ACH-000983	Leukemia	CCLE	PDTPGPE	DEG_SCF_FBW7_2	364:370	Mutation substituting flanking lysine	0.1667
p.G354D	KCL-22	haematopoietic and lymphoid tissue	COSMIC	PDTPGPE	DEG_SCF_FBW7_2	364:370	Mutation substituting flanking lysine	0.1667
p.R361C	ACH-001610	Brain Cancer	CCLE	PDTPGPE	DEG_SCF_FBW7_2	364:370	Mutation rewiring degron network	0.25

Kaplan plot for CORO6 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CORO6

UniProt ID: Q6QEF8

Entrez ID: 84940

Protein name: Coronin-6 (Coronin-like protein E) (Clipin-E)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CORO6 in