DegronMD

Uniprot ID: Q6QEF8

Source protein: Coronin-6

Source gene: CORO6

Class: DEG_SCF_FBW7_2

Location: 364:370

E3 ligase: FBXW7

DEGRON score: 0.799

ASA_SCORE: 72.4714

COIL: 0.9417

CONS_SCORE: 0.5718

DSS_SCORE: 0.6129

HELIX: 0.0144

FCONS_SCORE: 0.8321

RIG_SCORE: 0.6482

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L362M	TCGA-AP-A1E0	UCEC	TCGA	PDTPGPE	DEG_SCF_FBW7_2	0.2778
p.L362M	DO43154	UCEC	ICGC	PDTPGPE	DEG_SCF_FBW7_2	0.2778
p.Q359P	TCGA-BK-A6W3	UCEC	TCGA	PDTPGPE	DEG_SCF_FBW7_2	0.1944
p.Q359P	DO50076	UCEC	ICGC	PDTPGPE	DEG_SCF_FBW7_2	0.1944
p.D356H	TCGA-CR-6480	HNSC	TCGA	PDTPGPE	DEG_SCF_FBW7_2	0.1111
p.D356H	DO14296	HNSC	ICGC	PDTPGPE	DEG_SCF_FBW7_2	0.1111
p.D365N	TCGA-DK-A2I4	BLCA	TCGA	PDTPGPE	DEG_SCF_FBW7_2	0.5821
p.D365N	DO465	BLCA	ICGC	PDTPGPE	DEG_SCF_FBW7_2	0.5821
p.P367S	TCGA-FW-A3R5	SKCM	TCGA	PDTPGPE	DEG_SCF_FBW7_2	0.6752
p.P367S	DO37406	SKCM	ICGC	PDTPGPE	DEG_SCF_FBW7_2	0.6752
p.P364T	DO229028	LICA	ICGC	PDTPGPE	DEG_SCF_FBW7_2	0.7031
p.P364Q	DO229041	LICA	ICGC	PDTPGPE	DEG_SCF_FBW7_2	0.7035
p.F358L	SIDM01093	Cervical Carcinoma	GDSC	PDTPGPE	DEG_SCF_FBW7_2	0.1667
p.F358L	SiHa	cervix	COSMIC	PDTPGPE	DEG_SCF_FBW7_2	0.1667
p.E374Q	SIDM00963	Breast Carcinoma	GDSC	PDTPGPE	DEG_SCF_FBW7_2	0.2222
p.E374Q	BT-474	breast	COSMIC	PDTPGPE	DEG_SCF_FBW7_2	0.2222
p.G354D	ACH-000983	Leukemia	CCLE	PDTPGPE	DEG_SCF_FBW7_2	0.1667
p.G354D	KCL-22	haematopoietic_and_lymphoid_tissue	COSMIC	PDTPGPE	DEG_SCF_FBW7_2	0.1667
p.R361C	ACH-001610	Brain Cancer	CCLE	PDTPGPE	DEG_SCF_FBW7_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6QEF8	Coronin-6	DEG_SCF_FBW7_2	364:370	PDTPGPE	FBXW7	0.799	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons