DegronMD - Q6SJ96(TBPL2)

TBPL2

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P191H	TCGA-AP-A1DK	UCEC	TCGA	PMTPISE	DEG_SCF_FBW7_2	188:194	Mutation altering degron motif	0.7694
p.P191H	DO42033	UCEC	ICGC	PMTPISE	DEG_SCF_FBW7_2	188:194	Mutation altering degron motif	0.7694
p.P200L	TCGA-AX-A1CE	UCEC	TCGA	PMTPISE	DEG_SCF_FBW7_2	188:194	Mutation rewiring degron network	0.1667
p.P200L	DO42280	UCEC	ICGC	PMTPISE	DEG_SCF_FBW7_2	188:194	Mutation rewiring degron network	0.1667
p.S193L	TCGA-FR-A69P	SKCM	TCGA	PMTPISE	DEG_SCF_FBW7_2	188:194	Mutation altering degron motif	0.6556
p.S193L	DO47292	SKCM	ICGC	PMTPISE	DEG_SCF_FBW7_2	188:194	Mutation altering degron motif	0.6556
p.S182Y	TCGA-OR-A5JP	ACC	TCGA	PMTPISE	DEG_SCF_FBW7_2	188:194	Mutation rewiring degron network	0.1667
p.M189I	SIDM00193	Colorectal Carcinoma	GDSC	PMTPISE	DEG_SCF_FBW7_2	188:194	Mutation altering degron motif	0.6507
p.M189I	ACH-000991	Colon/Colorectal Cancer	CCLE	PMTPISE	DEG_SCF_FBW7_2	188:194	Mutation altering degron motif	0.6507
p.M189I	SNU-81	large intestine	COSMIC	PMTPISE	DEG_SCF_FBW7_2	188:194	Mutation altering degron motif	0.6507
p.I183M	SIDM00539	Esophageal Carcinoma	GDSC	PMTPISE	DEG_SCF_FBW7_2	188:194	Mutation rewiring degron network	0.1944
p.I183M	ACH-001496	Esophageal Cancer	CCLE	PMTPISE	DEG_SCF_FBW7_2	188:194	Mutation rewiring degron network	0.1944
p.I183M	ESO26	oesophagus	COSMIC	PMTPISE	DEG_SCF_FBW7_2	188:194	Mutation rewiring degron network	0.1944
p.P200S	ACH-001377	Pancreatic Cancer	CCLE	PMTPISE	DEG_SCF_FBW7_2	188:194	Mutation rewiring degron network	0.1667

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*NOTE: the Kaplan plots were collected from OncoLnc