DegronMD

Uniprot ID: Q6SJ96

Source protein: TATA box-binding protein-like 2

Source gene: TBPL2

Class: DEG_SCF_FBW7_2

Location: 188:194

E3 ligase: FBXW7

DEGRON score: 0.9364

ASA_SCORE: 79.0714

COIL: 0.7701

CONS_SCORE: 0.3804

DSS_SCORE: 0.2926

HELIX: 0.1604

FCONS_SCORE: 0.8922

RIG_SCORE: 0.7707

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P191H	TCGA-AP-A1DK	UCEC	TCGA	PMTPISE	DEG_SCF_FBW7_2	0.7694
p.P191H	DO42033	UCEC	ICGC	PMTPISE	DEG_SCF_FBW7_2	0.7694
p.P200L	TCGA-AX-A1CE	UCEC	TCGA	PMTPISE	DEG_SCF_FBW7_2	0.1667
p.P200L	DO42280	UCEC	ICGC	PMTPISE	DEG_SCF_FBW7_2	0.1667
p.S193L	TCGA-FR-A69P	SKCM	TCGA	PMTPISE	DEG_SCF_FBW7_2	0.6556
p.S193L	DO47292	SKCM	ICGC	PMTPISE	DEG_SCF_FBW7_2	0.6556
p.S182Y	TCGA-OR-A5JP	ACC	TCGA	PMTPISE	DEG_SCF_FBW7_2	0.1667
p.M189I	SIDM00193	Colorectal Carcinoma	GDSC	PMTPISE	DEG_SCF_FBW7_2	0.6507
p.M189I	ACH-000991	Colon/Colorectal Cancer	CCLE	PMTPISE	DEG_SCF_FBW7_2	0.6507
p.M189I	SNU-81	large_intestine	COSMIC	PMTPISE	DEG_SCF_FBW7_2	0.6507
p.I183M	SIDM00539	Esophageal Carcinoma	GDSC	PMTPISE	DEG_SCF_FBW7_2	0.1944
p.I183M	ACH-001496	Esophageal Cancer	CCLE	PMTPISE	DEG_SCF_FBW7_2	0.1944
p.I183M	ESO26	oesophagus	COSMIC	PMTPISE	DEG_SCF_FBW7_2	0.1944
p.P200S	ACH-001377	Pancreatic Cancer	CCLE	PMTPISE	DEG_SCF_FBW7_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6SJ96	TATA box-binding protein-like 2	DEG_SCF_FBW7_2	188:194	PMTPISE	FBXW7	0.9364	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons