DegronMD - Q6UW49(SPESP1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E136G	TCGA-55-7995	LUAD	TCGA	IVLHAE	LIG_APCC_ABBA_1	131:136	Mutation altering degron motif	0.7199
p.E136G	DO45323	LUAD	ICGC	IVLHAE	LIG_APCC_ABBA_1	131:136	Mutation altering degron motif	0.7199
p.S130P	TCGA-B5-A3FC	UCEC	TCGA	IVLHAE	LIG_APCC_ABBA_1	131:136	Mutation rewiring degron network	0.3056
p.S130P	DO41871	UCEC	ICGC	IVLHAE	LIG_APCC_ABBA_1	131:136	Mutation rewiring degron network	0.3056
p.P126S	TCGA-EE-A29E	SKCM	TCGA	IVLHAE	LIG_APCC_ABBA_1	131:136	Mutation rewiring degron network	0.1944
p.P126S	DO37831	SKCM	ICGC	IVLHAE	LIG_APCC_ABBA_1	131:136	Mutation rewiring degron network	0.1944
p.F121L	TCGA-G2-A3IE	BLCA	TCGA	IVLHAE	LIG_APCC_ABBA_1	131:136	Mutation rewiring degron network	0.0556
p.F121L	TCGA-GC-A3OO	BLCA	TCGA	IVLHAE	LIG_APCC_ABBA_1	131:136	Mutation rewiring degron network	0.0556
p.F121L	DO518	BLCA	ICGC	IVLHAE	LIG_APCC_ABBA_1	131:136	Mutation rewiring degron network	0.0556
p.F121L	DO767	BLCA	ICGC	IVLHAE	LIG_APCC_ABBA_1	131:136	Mutation rewiring degron network	0.0556
p.L133F	DO229010	COCA	ICGC	IVLHAE	LIG_APCC_ABBA_1	131:136	Mutation altering degron motif	0.6981
p.L133F	DO229013	COCA	ICGC	IVLHAE	LIG_APCC_ABBA_1	131:136	Mutation altering degron motif	0.6981
p.L133F	DO229016	COCA	ICGC	IVLHAE	LIG_APCC_ABBA_1	131:136	Mutation altering degron motif	0.6981
p.L133F	DO229480	LAML	ICGC	IVLHAE	LIG_APCC_ABBA_1	131:136	Mutation altering degron motif	0.6981
p.L133F	DO230659	LAML	ICGC	IVLHAE	LIG_APCC_ABBA_1	131:136	Mutation altering degron motif	0.6981
p.L133F	DO231140	LAML	ICGC	IVLHAE	LIG_APCC_ABBA_1	131:136	Mutation altering degron motif	0.6981
p.L133F	DO231075	LUSC	ICGC	IVLHAE	LIG_APCC_ABBA_1	131:136	Mutation altering degron motif	0.6981
p.E137K	DO222749	MELA	ICGC	IVLHAE	LIG_APCC_ABBA_1	131:136	Mutation rewiring degron network	0.3056

Kaplan plot for SPESP1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SPESP1

UniProt ID: Q6UW49

Entrez ID: 246777

Protein name: Sperm equatorial segment protein 1 (SP-ESP) (Equatorial segment protein) (ESP) (Glycosylated 38 kDa sperm protein C-7/8)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SPESP1 in