DegronMD

Uniprot ID: Q6UW49

Source protein: Sperm equatorial segment protein 1

Source gene: SPESP1

Class: LIG_APCC_ABBA_1

Location: 131:136

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5839

ASA_SCORE: 50.05

COIL: 0.3457

CONS_SCORE: 0.8068

DSS_SCORE: 0.4731

HELIX: 0.0267

FCONS_SCORE: 0.9712

RIG_SCORE: 0.7594

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E136G	TCGA-55-7995	LUAD	TCGA	IVLHAE	LIG_APCC_ABBA_1	0.7199
p.E136G	DO45323	LUAD	ICGC	IVLHAE	LIG_APCC_ABBA_1	0.7199
p.S130P	TCGA-B5-A3FC	UCEC	TCGA	IVLHAE	LIG_APCC_ABBA_1	0.3056
p.S130P	DO41871	UCEC	ICGC	IVLHAE	LIG_APCC_ABBA_1	0.3056
p.P126S	TCGA-EE-A29E	SKCM	TCGA	IVLHAE	LIG_APCC_ABBA_1	0.1944
p.P126S	DO37831	SKCM	ICGC	IVLHAE	LIG_APCC_ABBA_1	0.1944
p.F121L	TCGA-G2-A3IE	BLCA	TCGA	IVLHAE	LIG_APCC_ABBA_1	0.0556
p.F121L	TCGA-GC-A3OO	BLCA	TCGA	IVLHAE	LIG_APCC_ABBA_1	0.0556
p.F121L	DO518	BLCA	ICGC	IVLHAE	LIG_APCC_ABBA_1	0.0556
p.F121L	DO767	BLCA	ICGC	IVLHAE	LIG_APCC_ABBA_1	0.0556
p.L133F	DO229010	COCA	ICGC	IVLHAE	LIG_APCC_ABBA_1	0.6981
p.L133F	DO229013	COCA	ICGC	IVLHAE	LIG_APCC_ABBA_1	0.6981
p.L133F	DO229016	COCA	ICGC	IVLHAE	LIG_APCC_ABBA_1	0.6981
p.L133F	DO229480	LAML	ICGC	IVLHAE	LIG_APCC_ABBA_1	0.6981
p.L133F	DO230659	LAML	ICGC	IVLHAE	LIG_APCC_ABBA_1	0.6981
p.L133F	DO231140	LAML	ICGC	IVLHAE	LIG_APCC_ABBA_1	0.6981
p.L133F	DO231075	LUSC	ICGC	IVLHAE	LIG_APCC_ABBA_1	0.6981
p.E137K	DO222749	MELA	ICGC	IVLHAE	LIG_APCC_ABBA_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6UW49	Sperm equatorial segment protein 1	LIG_APCC_ABBA_1	131:136	IVLHAE	APC,CDC20,FZR1	0.5839	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons