DegronMD - Q6UWB4(PRSS55)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G33D	TCGA-44-6778	LUAD	TCGA	PRTPLPE	DEG_SCF_FBW7_2	20:26	Mutation rewiring degron network	0.1389
p.G33D	DO25603	LUAD	ICGC	PRTPLPE	DEG_SCF_FBW7_2	20:26	Mutation rewiring degron network	0.1389
p.R21Q	TCGA-BR-8487	STAD	TCGA	PRTPLPE	DEG_SCF_FBW7_2	20:26	Mutation altering degron motif	0.6218
p.R21Q	DO233918	GACA	ICGC	PRTPLPE	DEG_SCF_FBW7_2	20:26	Mutation altering degron motif	0.6218
p.R21Q	DO47867	STAD	ICGC	PRTPLPE	DEG_SCF_FBW7_2	20:26	Mutation altering degron motif	0.6218
p.R21Q	SIDM00650	Small Cell Lung Carcinoma	GDSC	PRTPLPE	DEG_SCF_FBW7_2	20:26	Mutation altering degron motif	0.6218
p.R21Q	SIDM01681	Non-Cancerous	GDSC	PRTPLPE	DEG_SCF_FBW7_2	20:26	Mutation altering degron motif	0.6218
p.G15E	TCGA-FW-A3R5	SKCM	TCGA	PRTPLPE	DEG_SCF_FBW7_2	20:26	Mutation rewiring degron network	0.1944
p.G15E	DO37406	SKCM	ICGC	PRTPLPE	DEG_SCF_FBW7_2	20:26	Mutation rewiring degron network	0.1944
p.G19S	TCGA-IB-7651	PAAD	TCGA	PRTPLPE	DEG_SCF_FBW7_2	20:26	Mutation rewiring degron network	0.3056
p.G19S	DO46657	PAAD	ICGC	PRTPLPE	DEG_SCF_FBW7_2	20:26	Mutation rewiring degron network	0.3056
p.T14K	TCGA-NC-A5HP	LUSC	TCGA	PRTPLPE	DEG_SCF_FBW7_2	20:26	Mutation rewiring degron network	0.1667
p.T14K	DO219199	LUSC	ICGC	PRTPLPE	DEG_SCF_FBW7_2	20:26	Mutation rewiring degron network	0.1667
p.T14M	TCGA-OL-A66N	BRCA	TCGA	PRTPLPE	DEG_SCF_FBW7_2	20:26	Mutation rewiring degron network	0.1667
p.T14M	DO44250	BRCA	ICGC	PRTPLPE	DEG_SCF_FBW7_2	20:26	Mutation rewiring degron network	0.1667
p.P25S	TCGA-YG-AA3N	SKCM	TCGA	PRTPLPE	DEG_SCF_FBW7_2	20:26	Mutation altering degron motif	0.5641
p.P25S	DO51298	SKCM	ICGC	PRTPLPE	DEG_SCF_FBW7_2	20:26	Mutation altering degron motif	0.5641
p.P25L	TCGA-YG-AA3N	SKCM	TCGA	PRTPLPE	DEG_SCF_FBW7_2	20:26	Mutation altering degron motif	0.6471
p.P25L	DO51298	SKCM	ICGC	PRTPLPE	DEG_SCF_FBW7_2	20:26	Mutation altering degron motif	0.6471
p.G15R	DO228483	BRCA	ICGC	PRTPLPE	DEG_SCF_FBW7_2	20:26	Mutation rewiring degron network	0.1944
p.G15R	DO222894	COCA	ICGC	PRTPLPE	DEG_SCF_FBW7_2	20:26	Mutation rewiring degron network	0.1944
p.G15R	DO229010	COCA	ICGC	PRTPLPE	DEG_SCF_FBW7_2	20:26	Mutation rewiring degron network	0.1944
p.G15R	DO229013	COCA	ICGC	PRTPLPE	DEG_SCF_FBW7_2	20:26	Mutation rewiring degron network	0.1944
p.G15R	DO229003	COCA	ICGC	PRTPLPE	DEG_SCF_FBW7_2	20:26	Mutation rewiring degron network	0.1944
p.G15R	DO229005	COCA	ICGC	PRTPLPE	DEG_SCF_FBW7_2	20:26	Mutation rewiring degron network	0.1944
p.G15R	DO234285	ESAD	ICGC	PRTPLPE	DEG_SCF_FBW7_2	20:26	Mutation rewiring degron network	0.1944
p.G15R	DO229346	LAML	ICGC	PRTPLPE	DEG_SCF_FBW7_2	20:26	Mutation rewiring degron network	0.1944
p.G15R	DO230659	LAML	ICGC	PRTPLPE	DEG_SCF_FBW7_2	20:26	Mutation rewiring degron network	0.1944
p.G15R	DO231140	LAML	ICGC	PRTPLPE	DEG_SCF_FBW7_2	20:26	Mutation rewiring degron network	0.1944
p.G15R	DO231075	LUSC	ICGC	PRTPLPE	DEG_SCF_FBW7_2	20:26	Mutation rewiring degron network	0.1944
p.G15R	DO231102	LUSC	ICGC	PRTPLPE	DEG_SCF_FBW7_2	20:26	Mutation rewiring degron network	0.1944
p.G15R	DO231201	LUSC	ICGC	PRTPLPE	DEG_SCF_FBW7_2	20:26	Mutation rewiring degron network	0.1944
p.R21W	DO228737	EOPC	ICGC	PRTPLPE	DEG_SCF_FBW7_2	20:26	Mutation altering degron motif	0.7523
p.R21L	DO229015	LICA	ICGC	PRTPLPE	DEG_SCF_FBW7_2	20:26	Mutation altering degron motif	0.7316
p.S11T	DO232855	NACA	ICGC	PRTPLPE	DEG_SCF_FBW7_2	20:26	Mutation rewiring degron network	0.0833
p.R36S	DO233296	NACA	ICGC	PRTPLPE	DEG_SCF_FBW7_2	20:26	Mutation rewiring degron network	0.0556
p.A27D	DO232224	PBCA	ICGC	PRTPLPE	DEG_SCF_FBW7_2	20:26	Mutation rewiring degron network	0.3056
p.A30T	SIDM00151	Ovarian Carcinoma	GDSC	PRTPLPE	DEG_SCF_FBW7_2	20:26	Mutation rewiring degron network	0.2222
p.A30T	ACH-000966	Ovarian Cancer	CCLE	PRTPLPE	DEG_SCF_FBW7_2	20:26	Mutation rewiring degron network	0.2222
p.A30T	IGROV-1	ovary	COSMIC	PRTPLPE	DEG_SCF_FBW7_2	20:26	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PRSS55

UniProt ID: Q6UWB4

Entrez ID: 203074

Protein name: Serine protease 55 (EC 3.4.21.-) (Testis serine protease 1) (T-SP1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PRSS55 in