DegronMD

Uniprot ID: Q6UWB4

Source protein: Serine protease 55

Source gene: PRSS55

Class: DEG_SCF_FBW7_2

Location: 20:26

E3 ligase: FBXW7

DEGRON score: 0.965

ASA_SCORE: 77

COIL: 0.7401

CONS_SCORE: 0.3392

DSS_SCORE: 0.3816

HELIX: 0.047

FCONS_SCORE: 1.1011

RIG_SCORE: 0.7229

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G33D	TCGA-44-6778	LUAD	TCGA	PRTPLPE	DEG_SCF_FBW7_2	0.1389
p.G33D	DO25603	LUAD	ICGC	PRTPLPE	DEG_SCF_FBW7_2	0.1389
p.R21Q	TCGA-BR-8487	STAD	TCGA	PRTPLPE	DEG_SCF_FBW7_2	0.6218
p.R21Q	DO233918	GACA	ICGC	PRTPLPE	DEG_SCF_FBW7_2	0.6218
p.R21Q	DO47867	STAD	ICGC	PRTPLPE	DEG_SCF_FBW7_2	0.6218
p.R21Q	SIDM00650	Small Cell Lung Carcinoma	GDSC	PRTPLPE	DEG_SCF_FBW7_2	0.6218
p.R21Q	SIDM01681	Non-Cancerous	GDSC	PRTPLPE	DEG_SCF_FBW7_2	0.6218
p.G15E	TCGA-FW-A3R5	SKCM	TCGA	PRTPLPE	DEG_SCF_FBW7_2	0.1944
p.G15E	DO37406	SKCM	ICGC	PRTPLPE	DEG_SCF_FBW7_2	0.1944
p.G19S	TCGA-IB-7651	PAAD	TCGA	PRTPLPE	DEG_SCF_FBW7_2	0.3056
p.G19S	DO46657	PAAD	ICGC	PRTPLPE	DEG_SCF_FBW7_2	0.3056
p.T14K	TCGA-NC-A5HP	LUSC	TCGA	PRTPLPE	DEG_SCF_FBW7_2	0.1667
p.T14K	DO219199	LUSC	ICGC	PRTPLPE	DEG_SCF_FBW7_2	0.1667
p.T14M	TCGA-OL-A66N	BRCA	TCGA	PRTPLPE	DEG_SCF_FBW7_2	0.1667
p.T14M	DO44250	BRCA	ICGC	PRTPLPE	DEG_SCF_FBW7_2	0.1667
p.P25S	TCGA-YG-AA3N	SKCM	TCGA	PRTPLPE	DEG_SCF_FBW7_2	0.5641
p.P25S	DO51298	SKCM	ICGC	PRTPLPE	DEG_SCF_FBW7_2	0.5641
p.P25L	TCGA-YG-AA3N	SKCM	TCGA	PRTPLPE	DEG_SCF_FBW7_2	0.6471
p.P25L	DO51298	SKCM	ICGC	PRTPLPE	DEG_SCF_FBW7_2	0.6471
p.G15R	DO228483	BRCA	ICGC	PRTPLPE	DEG_SCF_FBW7_2	0.1944
p.G15R	DO222894	COCA	ICGC	PRTPLPE	DEG_SCF_FBW7_2	0.1944
p.G15R	DO229010	COCA	ICGC	PRTPLPE	DEG_SCF_FBW7_2	0.1944
p.G15R	DO229013	COCA	ICGC	PRTPLPE	DEG_SCF_FBW7_2	0.1944
p.G15R	DO229003	COCA	ICGC	PRTPLPE	DEG_SCF_FBW7_2	0.1944
p.G15R	DO229005	COCA	ICGC	PRTPLPE	DEG_SCF_FBW7_2	0.1944
p.G15R	DO234285	ESAD	ICGC	PRTPLPE	DEG_SCF_FBW7_2	0.1944
p.G15R	DO229346	LAML	ICGC	PRTPLPE	DEG_SCF_FBW7_2	0.1944
p.G15R	DO230659	LAML	ICGC	PRTPLPE	DEG_SCF_FBW7_2	0.1944
p.G15R	DO231140	LAML	ICGC	PRTPLPE	DEG_SCF_FBW7_2	0.1944
p.G15R	DO231075	LUSC	ICGC	PRTPLPE	DEG_SCF_FBW7_2	0.1944
p.G15R	DO231102	LUSC	ICGC	PRTPLPE	DEG_SCF_FBW7_2	0.1944
p.G15R	DO231201	LUSC	ICGC	PRTPLPE	DEG_SCF_FBW7_2	0.1944
p.R21W	DO228737	EOPC	ICGC	PRTPLPE	DEG_SCF_FBW7_2	0.7523
p.R21L	DO229015	LICA	ICGC	PRTPLPE	DEG_SCF_FBW7_2	0.7316
p.S11T	DO232855	NACA	ICGC	PRTPLPE	DEG_SCF_FBW7_2	0.0833
p.R36S	DO233296	NACA	ICGC	PRTPLPE	DEG_SCF_FBW7_2	0.0556
p.A27D	DO232224	PBCA	ICGC	PRTPLPE	DEG_SCF_FBW7_2	0.3056
p.A30T	SIDM00151	Ovarian Carcinoma	GDSC	PRTPLPE	DEG_SCF_FBW7_2	0.2222
p.A30T	ACH-000966	Ovarian Cancer	CCLE	PRTPLPE	DEG_SCF_FBW7_2	0.2222
p.A30T	IGROV-1	ovary	COSMIC	PRTPLPE	DEG_SCF_FBW7_2	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PRTPLPE

Degron related mutations and impact score

Drug responses associated with PRSS55 mutations

All proteins holding degron of PRTPLPE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6UWB4	Serine protease 55	DEG_SCF_FBW7_2	20:26	PRTPLPE	FBXW7	0.965	More...