DegronMD - Q6UWF7(NXPE4)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K56E	TCGA-13-1500	OV	TCGA	PKTPLIS	DEG_SCF_FBW7_1	55:61	Mutation altering degron motif	0.591
p.L65Q	TCGA-34-5231	LUSC	TCGA	PKTPLIS	DEG_SCF_FBW7_1	55:61	Mutation rewiring degron network	0.2222
p.L65Q	DO26772	LUSC	ICGC	PKTPLIS	DEG_SCF_FBW7_1	55:61	Mutation rewiring degron network	0.2222
p.S49C	TCGA-43-8115	LUSC	TCGA	PKTPLIS	DEG_SCF_FBW7_1	55:61	Mutation rewiring degron network	0.1667
p.L53S	TCGA-55-7724	LUAD	TCGA	PKTPLIS	DEG_SCF_FBW7_1	55:61	Mutation rewiring degron network	0.2778
p.L53S	DO45373	LUAD	ICGC	PKTPLIS	DEG_SCF_FBW7_1	55:61	Mutation rewiring degron network	0.2778
p.I60T	TCGA-55-7995	LUAD	TCGA	PKTPLIS	DEG_SCF_FBW7_1	55:61	Mutation altering degron motif	0.5966
p.I60T	DO45323	LUAD	ICGC	PKTPLIS	DEG_SCF_FBW7_1	55:61	Mutation altering degron motif	0.5966
p.S52T	TCGA-56-A49D	LUSC	TCGA	PKTPLIS	DEG_SCF_FBW7_1	55:61	Mutation rewiring degron network	0.25
p.S52T	DO45475	LUSC	ICGC	PKTPLIS	DEG_SCF_FBW7_1	55:61	Mutation rewiring degron network	0.25
p.L65P	TCGA-68-7757	LUSC	TCGA	PKTPLIS	DEG_SCF_FBW7_1	55:61	Mutation rewiring degron network	0.2222
p.L65P	DO26886	LUSC	ICGC	PKTPLIS	DEG_SCF_FBW7_1	55:61	Mutation rewiring degron network	0.2222
p.L70I	TCGA-77-8128	LUSC	TCGA	PKTPLIS	DEG_SCF_FBW7_1	55:61	Mutation rewiring degron network	0.0833
p.L70I	DO26464	LUSC	ICGC	PKTPLIS	DEG_SCF_FBW7_1	55:61	Mutation rewiring degron network	0.0833
p.E67K	TCGA-D3-A2JN	SKCM	TCGA	PKTPLIS	DEG_SCF_FBW7_1	55:61	Mutation rewiring degron network	0.1667
p.E67K	DO229050	LICA	ICGC	PKTPLIS	DEG_SCF_FBW7_1	55:61	Mutation rewiring degron network	0.1667
p.E67K	DO47590	SKCM	ICGC	PKTPLIS	DEG_SCF_FBW7_1	55:61	Mutation rewiring degron network	0.1667
p.S61L	TCGA-FW-A5DX	SKCM	TCGA	PKTPLIS	DEG_SCF_FBW7_1	55:61	Mutation altering degron motif	0.8778
p.S61L	DO47253	SKCM	ICGC	PKTPLIS	DEG_SCF_FBW7_1	55:61	Mutation altering degron motif	0.8778
p.S49Y	TCGA-NC-A5HD	LUSC	TCGA	PKTPLIS	DEG_SCF_FBW7_1	55:61	Mutation rewiring degron network	0.1667
p.S49Y	DO219184	LUSC	ICGC	PKTPLIS	DEG_SCF_FBW7_1	55:61	Mutation rewiring degron network	0.1667
p.R71C	DO8192	COAD	ICGC	PKTPLIS	DEG_SCF_FBW7_1	55:61	Mutation rewiring degron network	0.0556
p.R71C	DO51446	PRAD	ICGC	PKTPLIS	DEG_SCF_FBW7_1	55:61	Mutation rewiring degron network	0.0556
p.T66K	DO223149	ESCA	ICGC	PKTPLIS	DEG_SCF_FBW7_1	55:61	Mutation blocking phosphorylation signal	0.6389
p.W46G	DO233686	GACA	ICGC	PKTPLIS	DEG_SCF_FBW7_1	55:61	Mutation rewiring degron network	0.0833
p.S47N	DO44473	KIRP	ICGC	PKTPLIS	DEG_SCF_FBW7_1	55:61	Mutation rewiring degron network	0.1111
p.L57Q	DO228947	LICA	ICGC	PKTPLIS	DEG_SCF_FBW7_1	55:61	Mutation altering degron motif	0.7765
p.E69K	DO229050	LICA	ICGC	PKTPLIS	DEG_SCF_FBW7_1	55:61	Mutation rewiring degron network	0.1111
p.M53T	DO44660	LICA	ICGC	PKTPLIS	DEG_SCF_FBW7_1	55:61	Mutation rewiring degron network	0.2778
p.T50A	DO24421	LUAD	ICGC	PKTPLIS	DEG_SCF_FBW7_1	55:61	Mutation rewiring degron network	0.1944
p.A49T	DO24150	LUAD	ICGC	PKTPLIS	DEG_SCF_FBW7_1	55:61	Mutation rewiring degron network	0.1667
p.G59E	DO222749	MELA	ICGC	PKTPLIS	DEG_SCF_FBW7_1	55:61	Mutation altering degron motif	0.7199
p.G59E	DO222880	MELA	ICGC	PKTPLIS	DEG_SCF_FBW7_1	55:61	Mutation altering degron motif	0.7199
p.G59E	DO229446	SKCA	ICGC	PKTPLIS	DEG_SCF_FBW7_1	55:61	Mutation altering degron motif	0.7199
p.R71L	DO219345	PRAD	ICGC	PKTPLIS	DEG_SCF_FBW7_1	55:61	Mutation rewiring degron network	0.0556
p.G59R	DO219313	PRAD	ICGC	PKTPLIS	DEG_SCF_FBW7_1	55:61	Mutation altering degron motif	0.7568
p.M65I	DO37839	SKCM	ICGC	PKTPLIS	DEG_SCF_FBW7_1	55:61	Mutation rewiring degron network	0.2222
p.R71S	DO41235	UCEC	ICGC	PKTPLIS	DEG_SCF_FBW7_1	55:61	Mutation rewiring degron network	0.0556
p.R71S	NK-92MI	haematopoietic and lymphoid tissue	COSMIC	PKTPLIS	DEG_SCF_FBW7_1	55:61	Mutation rewiring degron network	0.0556
p.F54S	SIDM00773	Non-Cancerous	GDSC	PKTPLIS	DEG_SCF_FBW7_1	55:61	Mutation rewiring degron network	0.3056
p.F54S	SIDM00774	Breast Carcinoma	GDSC	PKTPLIS	DEG_SCF_FBW7_1	55:61	Mutation rewiring degron network	0.3056
p.F54L	ACH-000563	Lung Cancer	CCLE	PKTPLIS	DEG_SCF_FBW7_1	55:61	Mutation rewiring degron network	0.3056
p.T57R	ACH-001484	Leukemia	CCLE	PKTPLIS	DEG_SCF_FBW7_1	55:61	Mutation altering degron motif	0.7876
p.T57R	ACH-001485	Leukemia	CCLE	PKTPLIS	DEG_SCF_FBW7_1	55:61	Mutation altering degron motif	0.7876
p.S45Y	NCI-H2110	lung	COSMIC	PKTPLIS	DEG_SCF_FBW7_1	55:61	Mutation rewiring degron network	0.0556
p.I62T	HH	haematopoietic and lymphoid tissue	COSMIC	PKTPLIS	DEG_SCF_FBW7_1	55:61	Mutation rewiring degron network	0.3056
p.R71H	HOP-62	lung	COSMIC	PKTPLIS	DEG_SCF_FBW7_1	55:61	Mutation rewiring degron network	0.0556
p.M53I	NCI-H2227	lung	COSMIC	PKTPLIS	DEG_SCF_FBW7_1	55:61	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NXPE4

UniProt ID: Q6UWF7

Entrez ID: 54827

Protein name: NXPE family member 4 (Protein FAM55D)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for NXPE4 in