DegronMD

Uniprot ID: Q6UWF7

Source protein: NXPE family member 4

Source gene: NXPE4

Class: DEG_SCF_FBW7_1

Location: 55:61

E3 ligase: FBXW7

DEGRON score: 0.6197

ASA_SCORE: 80

COIL: 0.9137

CONS_SCORE: 0.2508

DSS_SCORE: 0.2255

HELIX: 0.0317

FCONS_SCORE: 0.9497

RIG_SCORE: 0.8029

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K56E	TCGA-13-1500	OV	TCGA	PKTPLIS	DEG_SCF_FBW7_1	0.591
p.L65Q	TCGA-34-5231	LUSC	TCGA	PKTPLIS	DEG_SCF_FBW7_1	0.2222
p.L65Q	DO26772	LUSC	ICGC	PKTPLIS	DEG_SCF_FBW7_1	0.2222
p.S49C	TCGA-43-8115	LUSC	TCGA	PKTPLIS	DEG_SCF_FBW7_1	0.1667
p.L53S	TCGA-55-7724	LUAD	TCGA	PKTPLIS	DEG_SCF_FBW7_1	0.2778
p.L53S	DO45373	LUAD	ICGC	PKTPLIS	DEG_SCF_FBW7_1	0.2778
p.I60T	TCGA-55-7995	LUAD	TCGA	PKTPLIS	DEG_SCF_FBW7_1	0.5966
p.I60T	DO45323	LUAD	ICGC	PKTPLIS	DEG_SCF_FBW7_1	0.5966
p.S52T	TCGA-56-A49D	LUSC	TCGA	PKTPLIS	DEG_SCF_FBW7_1	0.25
p.S52T	DO45475	LUSC	ICGC	PKTPLIS	DEG_SCF_FBW7_1	0.25
p.L65P	TCGA-68-7757	LUSC	TCGA	PKTPLIS	DEG_SCF_FBW7_1	0.2222
p.L65P	DO26886	LUSC	ICGC	PKTPLIS	DEG_SCF_FBW7_1	0.2222
p.L70I	TCGA-77-8128	LUSC	TCGA	PKTPLIS	DEG_SCF_FBW7_1	0.0833
p.L70I	DO26464	LUSC	ICGC	PKTPLIS	DEG_SCF_FBW7_1	0.0833
p.E67K	TCGA-D3-A2JN	SKCM	TCGA	PKTPLIS	DEG_SCF_FBW7_1	0.1667
p.E67K	DO229050	LICA	ICGC	PKTPLIS	DEG_SCF_FBW7_1	0.1667
p.E67K	DO47590	SKCM	ICGC	PKTPLIS	DEG_SCF_FBW7_1	0.1667
p.S61L	TCGA-FW-A5DX	SKCM	TCGA	PKTPLIS	DEG_SCF_FBW7_1	0.8778
p.S61L	DO47253	SKCM	ICGC	PKTPLIS	DEG_SCF_FBW7_1	0.8778
p.S49Y	TCGA-NC-A5HD	LUSC	TCGA	PKTPLIS	DEG_SCF_FBW7_1	0.1667
p.S49Y	DO219184	LUSC	ICGC	PKTPLIS	DEG_SCF_FBW7_1	0.1667
p.R71C	DO8192	COAD	ICGC	PKTPLIS	DEG_SCF_FBW7_1	0.0556
p.R71C	DO51446	PRAD	ICGC	PKTPLIS	DEG_SCF_FBW7_1	0.0556
p.T66K	DO223149	ESCA	ICGC	PKTPLIS	DEG_SCF_FBW7_1	0.6389
p.W46G	DO233686	GACA	ICGC	PKTPLIS	DEG_SCF_FBW7_1	0.0833
p.S47N	DO44473	KIRP	ICGC	PKTPLIS	DEG_SCF_FBW7_1	0.1111
p.L57Q	DO228947	LICA	ICGC	PKTPLIS	DEG_SCF_FBW7_1	0.7765
p.E69K	DO229050	LICA	ICGC	PKTPLIS	DEG_SCF_FBW7_1	0.1111
p.M53T	DO44660	LICA	ICGC	PKTPLIS	DEG_SCF_FBW7_1	0.2778
p.T50A	DO24421	LUAD	ICGC	PKTPLIS	DEG_SCF_FBW7_1	0.1944
p.A49T	DO24150	LUAD	ICGC	PKTPLIS	DEG_SCF_FBW7_1	0.1667
p.G59E	DO222749	MELA	ICGC	PKTPLIS	DEG_SCF_FBW7_1	0.7199
p.G59E	DO222880	MELA	ICGC	PKTPLIS	DEG_SCF_FBW7_1	0.7199
p.G59E	DO229446	SKCA	ICGC	PKTPLIS	DEG_SCF_FBW7_1	0.7199
p.R71L	DO219345	PRAD	ICGC	PKTPLIS	DEG_SCF_FBW7_1	0.0556
p.G59R	DO219313	PRAD	ICGC	PKTPLIS	DEG_SCF_FBW7_1	0.7568
p.M65I	DO37839	SKCM	ICGC	PKTPLIS	DEG_SCF_FBW7_1	0.2222
p.R71S	DO41235	UCEC	ICGC	PKTPLIS	DEG_SCF_FBW7_1	0.0556
p.R71S	NK-92MI	haematopoietic_and_lymphoid_tissue	COSMIC	PKTPLIS	DEG_SCF_FBW7_1	0.0556
p.F54S	SIDM00773	Non-Cancerous	GDSC	PKTPLIS	DEG_SCF_FBW7_1	0.3056
p.F54S	SIDM00774	Breast Carcinoma	GDSC	PKTPLIS	DEG_SCF_FBW7_1	0.3056
p.F54L	ACH-000563	Lung Cancer	CCLE	PKTPLIS	DEG_SCF_FBW7_1	0.3056
p.T57R	ACH-001484	Leukemia	CCLE	PKTPLIS	DEG_SCF_FBW7_1	0.7876
p.T57R	ACH-001485	Leukemia	CCLE	PKTPLIS	DEG_SCF_FBW7_1	0.7876
p.S45Y	NCI-H2110	lung	COSMIC	PKTPLIS	DEG_SCF_FBW7_1	0.0556
p.I62T	HH	haematopoietic_and_lymphoid_tissue	COSMIC	PKTPLIS	DEG_SCF_FBW7_1	0.3056
p.R71H	HOP-62	lung	COSMIC	PKTPLIS	DEG_SCF_FBW7_1	0.0556
p.M53I	NCI-H2227	lung	COSMIC	PKTPLIS	DEG_SCF_FBW7_1	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PKTPLIS

Degron related mutations and impact score

Drug responses associated with NXPE4 mutations

All proteins holding degron of PKTPLIS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6UWF7	NXPE family member 4	DEG_SCF_FBW7_1	55:61	PKTPLIS	FBXW7	0.6197	More...