DegronMD - Q6UWL6(KIRREL2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A518S	TCGA-17-Z031	LUAD	TCGA	RRDLLPTVR	DEG_APCC_DBOX_1	502:510	Mutation rewiring degron network	0.1111
p.T508N	TCGA-39-5021	LUSC	TCGA	RRDLLPTVR	DEG_APCC_DBOX_1	502:510	Mutation altering degron motif	0.7055
p.T508N	DO27397	LUSC	ICGC	RRDLLPTVR	DEG_APCC_DBOX_1	502:510	Mutation altering degron motif	0.7055
p.G494V	TCGA-85-8070	LUSC	TCGA	RRDLLPTVR	DEG_APCC_DBOX_1	502:510	Mutation rewiring degron network	0.1111
p.G494V	DO26581	LUSC	ICGC	RRDLLPTVR	DEG_APCC_DBOX_1	502:510	Mutation rewiring degron network	0.1111
p.G495C	TCGA-A1-A0SO	BRCA	TCGA	RRDLLPTVR	DEG_APCC_DBOX_1	502:510	Mutation rewiring degron network	0.1389
p.G495C	DO2020	BRCA	ICGC	RRDLLPTVR	DEG_APCC_DBOX_1	502:510	Mutation rewiring degron network	0.1389
p.G514E	DO225005	BRCA	ICGC	RRDLLPTVR	DEG_APCC_DBOX_1	502:510	Mutation rewiring degron network	0.2222
p.E493K	DO234299	ESAD	ICGC	RRDLLPTVR	DEG_APCC_DBOX_1	502:510	Mutation rewiring degron network	0.0833
p.E493K	DO233169	GACA	ICGC	RRDLLPTVR	DEG_APCC_DBOX_1	502:510	Mutation rewiring degron network	0.0833
p.R510W	SIDM00487	Colorectal Carcinoma	GDSC	RRDLLPTVR	DEG_APCC_DBOX_1	502:510	Mutation altering degron motif	0.7523
p.R510W	ACH-000963	Colon/Colorectal Cancer	CCLE	RRDLLPTVR	DEG_APCC_DBOX_1	502:510	Mutation altering degron motif	0.7523
p.R501Q	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	RRDLLPTVR	DEG_APCC_DBOX_1	502:510	Mutation rewiring degron network	0.3056
p.R516Q	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	RRDLLPTVR	DEG_APCC_DBOX_1	502:510	Mutation rewiring degron network	0.1667
p.F493L	NCI-H3122	lung	COSMIC	RRDLLPTVR	DEG_APCC_DBOX_1	502:510	Mutation rewiring degron network	0.0833
p.F508L	NCI-H3122	lung	COSMIC	RRDLLPTVR	DEG_APCC_DBOX_1	502:510	Mutation altering degron motif	0.6981

Kaplan plot for KIRREL2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KIRREL2

UniProt ID: Q6UWL6

Entrez ID: 84063

Protein name: Kin of IRRE-like protein 2 (Kin of irregular chiasm-like protein 2) (Nephrin-like protein 3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KIRREL2 in