DegronMD

Uniprot ID: Q6UWL6

Source protein: Kin of IRRE-like protein 2

Source gene: KIRREL2

Class: DEG_APCC_DBOX_1

Location: 502:510

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.922

ASA_SCORE: 80.0889

COIL: 0.5783

CONS_SCORE: 0.435

DSS_SCORE: 0.1416

HELIX: 0.0201

FCONS_SCORE: 1.2726

RIG_SCORE: 0.856

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A518S	TCGA-17-Z031	LUAD	TCGA	RRDLLPTVR	DEG_APCC_DBOX_1	0.1111
p.T508N	TCGA-39-5021	LUSC	TCGA	RRDLLPTVR	DEG_APCC_DBOX_1	0.7055
p.T508N	DO27397	LUSC	ICGC	RRDLLPTVR	DEG_APCC_DBOX_1	0.7055
p.G494V	TCGA-85-8070	LUSC	TCGA	RRDLLPTVR	DEG_APCC_DBOX_1	0.1111
p.G494V	DO26581	LUSC	ICGC	RRDLLPTVR	DEG_APCC_DBOX_1	0.1111
p.G495C	TCGA-A1-A0SO	BRCA	TCGA	RRDLLPTVR	DEG_APCC_DBOX_1	0.1389
p.G495C	DO2020	BRCA	ICGC	RRDLLPTVR	DEG_APCC_DBOX_1	0.1389
p.G514E	DO225005	BRCA	ICGC	RRDLLPTVR	DEG_APCC_DBOX_1	0.2222
p.E493K	DO234299	ESAD	ICGC	RRDLLPTVR	DEG_APCC_DBOX_1	0.0833
p.E493K	DO233169	GACA	ICGC	RRDLLPTVR	DEG_APCC_DBOX_1	0.0833
p.R510W	SIDM00487	Colorectal Carcinoma	GDSC	RRDLLPTVR	DEG_APCC_DBOX_1	0.7523
p.R510W	ACH-000963	Colon/Colorectal Cancer	CCLE	RRDLLPTVR	DEG_APCC_DBOX_1	0.7523
p.R501Q	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	RRDLLPTVR	DEG_APCC_DBOX_1	0.3056
p.R516Q	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	RRDLLPTVR	DEG_APCC_DBOX_1	0.1667
p.F493L	NCI-H3122	lung	COSMIC	RRDLLPTVR	DEG_APCC_DBOX_1	0.0833
p.F508L	NCI-H3122	lung	COSMIC	RRDLLPTVR	DEG_APCC_DBOX_1	0.6981

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6UWL6	Kin of IRRE-like protein 2	DEG_APCC_DBOX_1	502:510	RRDLLPTVR	APC,CDC20,FZR1	0.922	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons