DegronMD - Q6UX04(CWC27)

CWC27

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P176S	TCGA-18-3409	LUSC	TCGA	FNPFDD	LIG_APCC_ABBA_1	168:173	Mutation rewiring degron network	0.25
p.P176S	DO26444	LUSC	ICGC	FNPFDD	LIG_APCC_ABBA_1	168:173	Mutation rewiring degron network	0.25
p.R177K	TCGA-69-7978	LUAD	TCGA	FNPFDD	LIG_APCC_ABBA_1	168:173	Mutation rewiring degron network	0.2222
p.R177K	DO24920	LUAD	ICGC	FNPFDD	LIG_APCC_ABBA_1	168:173	Mutation rewiring degron network	0.2222
p.I179M	TCGA-CA-6717	COAD	TCGA	FNPFDD	LIG_APCC_ABBA_1	168:173	Mutation rewiring degron network	0.1667
p.I179M	DO8264	COAD	ICGC	FNPFDD	LIG_APCC_ABBA_1	168:173	Mutation rewiring degron network	0.1667
p.P170A	TCGA-XF-A9T6	BLCA	TCGA	FNPFDD	LIG_APCC_ABBA_1	168:173	Mutation altering degron motif	0.7503
p.P170A	DO51926	BLCA	ICGC	FNPFDD	LIG_APCC_ABBA_1	168:173	Mutation altering degron motif	0.7503
p.D172Y	DO229028	LICA	ICGC	FNPFDD	LIG_APCC_ABBA_1	168:173	Mutation altering degron motif	0.6214
p.L167F	DO229026	LICA	ICGC	FNPFDD	LIG_APCC_ABBA_1	168:173	Mutation rewiring degron network	0.3056
p.E165G	DO229272	THCA	ICGC	FNPFDD	LIG_APCC_ABBA_1	168:173	Mutation rewiring degron network	0.25
p.P158Q	DO229213	THCA	ICGC	FNPFDD	LIG_APCC_ABBA_1	168:173	Mutation rewiring degron network	0.0556

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*NOTE: the Kaplan plots were collected from OncoLnc