DegronMD

Uniprot ID: Q6UX04

Source protein: Spliceosome-associated protein CWC27 homolog

Source gene: CWC27

Class: LIG_APCC_ABBA_1

Location: 168:173

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.647

ASA_SCORE: 60.6

COIL: 0.666

CONS_SCORE: 0.5056

DSS_SCORE: 0.3049

HELIX: 0.2407

FCONS_SCORE: 1.2906

RIG_SCORE: 0.8028

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P176S	TCGA-18-3409	LUSC	TCGA	FNPFDD	LIG_APCC_ABBA_1	0.25
p.P176S	DO26444	LUSC	ICGC	FNPFDD	LIG_APCC_ABBA_1	0.25
p.R177K	TCGA-69-7978	LUAD	TCGA	FNPFDD	LIG_APCC_ABBA_1	0.2222
p.R177K	DO24920	LUAD	ICGC	FNPFDD	LIG_APCC_ABBA_1	0.2222
p.I179M	TCGA-CA-6717	COAD	TCGA	FNPFDD	LIG_APCC_ABBA_1	0.1667
p.I179M	DO8264	COAD	ICGC	FNPFDD	LIG_APCC_ABBA_1	0.1667
p.P170A	TCGA-XF-A9T6	BLCA	TCGA	FNPFDD	LIG_APCC_ABBA_1	0.7503
p.P170A	DO51926	BLCA	ICGC	FNPFDD	LIG_APCC_ABBA_1	0.7503
p.D172Y	DO229028	LICA	ICGC	FNPFDD	LIG_APCC_ABBA_1	0.6214
p.L167F	DO229026	LICA	ICGC	FNPFDD	LIG_APCC_ABBA_1	0.3056
p.E165G	DO229272	THCA	ICGC	FNPFDD	LIG_APCC_ABBA_1	0.25
p.P158Q	DO229213	THCA	ICGC	FNPFDD	LIG_APCC_ABBA_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6UX04	Spliceosome-associated protein CWC27 homolog	LIG_APCC_ABBA_1	168:173	FNPFDD	APC,CDC20,FZR1	0.647	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons