DegronMD - Q6UX15(LAYN)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S314L	TCGA-21-1079	LUSC	TCGA	TRPDLKNIS	DEG_APCC_DBOX_1	306:314	Mutation altering degron motif	0.6556
p.S314L	TCGA-DA-A1HV	SKCM	TCGA	TRPDLKNIS	DEG_APCC_DBOX_1	306:314	Mutation altering degron motif	0.6556
p.S314L	DO26846	LUSC	ICGC	TRPDLKNIS	DEG_APCC_DBOX_1	306:314	Mutation altering degron motif	0.6556
p.S314L	DO37659	SKCM	ICGC	TRPDLKNIS	DEG_APCC_DBOX_1	306:314	Mutation altering degron motif	0.6556
p.R307W	TCGA-R5-A805	STAD	TCGA	TRPDLKNIS	DEG_APCC_DBOX_1	306:314	Mutation altering degron motif	0.8634
p.R307L	DO229026	LICA	ICGC	TRPDLKNIS	DEG_APCC_DBOX_1	306:314	Mutation altering degron motif	0.8428
p.R307Q	DO23549	LIRI	ICGC	TRPDLKNIS	DEG_APCC_DBOX_1	306:314	Mutation altering degron motif	0.7329
p.R316Q	DO46790	PRAD	ICGC	TRPDLKNIS	DEG_APCC_DBOX_1	306:314	Mutation rewiring degron network	0.2778

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons