DegronMD

Uniprot ID: Q6UX15

Source protein: Layilin

Source gene: LAYN

Class: DEG_APCC_DBOX_1

Location: 306:314

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8681

ASA_SCORE: 65.3333

COIL: 0.6493

CONS_SCORE: 0.3691

DSS_SCORE: 0.3817

HELIX: 0.2414

FCONS_SCORE: 0.9161

RIG_SCORE: 0.7866

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S314L	TCGA-21-1079	LUSC	TCGA	TRPDLKNIS	DEG_APCC_DBOX_1	0.6556
p.S314L	TCGA-DA-A1HV	SKCM	TCGA	TRPDLKNIS	DEG_APCC_DBOX_1	0.6556
p.S314L	DO26846	LUSC	ICGC	TRPDLKNIS	DEG_APCC_DBOX_1	0.6556
p.S314L	DO37659	SKCM	ICGC	TRPDLKNIS	DEG_APCC_DBOX_1	0.6556
p.R307W	TCGA-R5-A805	STAD	TCGA	TRPDLKNIS	DEG_APCC_DBOX_1	0.8634
p.R307L	DO229026	LICA	ICGC	TRPDLKNIS	DEG_APCC_DBOX_1	0.8428
p.R307Q	DO23549	LIRI	ICGC	TRPDLKNIS	DEG_APCC_DBOX_1	0.7329
p.R316Q	DO46790	PRAD	ICGC	TRPDLKNIS	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6UX15	Layilin	DEG_APCC_DBOX_1	306:314	TRPDLKNIS	APC,CDC20,FZR1	0.8681	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons