DegronMD - Q6UX39(AMTN)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P173L	TCGA-AA-3947	COAD	TCGA	LPTPSGT	DEG_SCF_FBW7_1	172:178	Mutation altering degron motif	0.6471
p.P162S	TCGA-D3-A8GS	SKCM	TCGA	LPTPSGT	DEG_SCF_FBW7_1	172:178	Mutation rewiring degron network	0.0556
p.Q165H	TCGA-DD-AACJ	LIHC	TCGA	LPTPSGT	DEG_SCF_FBW7_1	172:178	Mutation rewiring degron network	0.1389
p.Q165H	TCGA-EE-A29G	SKCM	TCGA	LPTPSGT	DEG_SCF_FBW7_1	172:178	Mutation rewiring degron network	0.1389
p.P187S	TCGA-EO-A22U	UCEC	TCGA	LPTPSGT	DEG_SCF_FBW7_1	172:178	Mutation rewiring degron network	0.0833
p.V184M	TCGA-FR-A7U9	SKCM	TCGA	LPTPSGT	DEG_SCF_FBW7_1	172:178	Mutation rewiring degron network	0.1667
p.V184M	TCGA-ZF-A9R5	BLCA	TCGA	LPTPSGT	DEG_SCF_FBW7_1	172:178	Mutation rewiring degron network	0.1667
p.D181N	TCGA-ZF-AA53	BLCA	TCGA	LPTPSGT	DEG_SCF_FBW7_1	172:178	Mutation rewiring degron network	0.25
p.D180N	DO219096	BLCA	ICGC	LPTPSGT	DEG_SCF_FBW7_1	172:178	Mutation rewiring degron network	0.2778
p.V183M	DO219063	BLCA	ICGC	LPTPSGT	DEG_SCF_FBW7_1	172:178	Mutation rewiring degron network	0.1944
p.V183M	DO48546	SKCM	ICGC	LPTPSGT	DEG_SCF_FBW7_1	172:178	Mutation rewiring degron network	0.1944
p.P172L	DO8192	COAD	ICGC	LPTPSGT	DEG_SCF_FBW7_1	172:178	Mutation altering degron motif	0.7582
p.P172L	DO220900	MELA	ICGC	LPTPSGT	DEG_SCF_FBW7_1	172:178	Mutation altering degron motif	0.7582
p.R170C	DO227997	COCA	ICGC	LPTPSGT	DEG_SCF_FBW7_1	172:178	Mutation rewiring degron network	0.2778
p.Q164H	DO52206	LIHC	ICGC	LPTPSGT	DEG_SCF_FBW7_1	172:178	Mutation rewiring degron network	0.1111
p.Q164H	DO47303	SKCM	ICGC	LPTPSGT	DEG_SCF_FBW7_1	172:178	Mutation rewiring degron network	0.1111
p.G188S	DO45509	LUSC	ICGC	LPTPSGT	DEG_SCF_FBW7_1	172:178	Mutation rewiring degron network	0.0556
p.P174L	DO220886	MELA	ICGC	LPTPSGT	DEG_SCF_FBW7_1	172:178	Mutation altering degron motif	0.7582
p.P186S	DO43755	UCEC	ICGC	LPTPSGT	DEG_SCF_FBW7_1	172:178	Mutation rewiring degron network	0.1111
p.R171H	SIDM00232	Kidney Carcinoma	GDSC	LPTPSGT	DEG_SCF_FBW7_1	172:178	Mutation rewiring degron network	0.3056
p.R171H	SIDM01622	Breast Carcinoma	GDSC	LPTPSGT	DEG_SCF_FBW7_1	172:178	Mutation rewiring degron network	0.3056
p.G177V	SIDM00845	Burkitt's Lymphoma	GDSC	LPTPSGT	DEG_SCF_FBW7_1	172:178	Mutation altering degron motif	0.6421
p.G177V	SIDM00393	Gastric Carcinoma	GDSC	LPTPSGT	DEG_SCF_FBW7_1	172:178	Mutation altering degron motif	0.6421
p.G177V	SIDM00269	Ewing's Sarcoma	GDSC	LPTPSGT	DEG_SCF_FBW7_1	172:178	Mutation altering degron motif	0.6421
p.G177V	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	LPTPSGT	DEG_SCF_FBW7_1	172:178	Mutation altering degron motif	0.6421
p.G177V	SIDM01318	Hepatocellular Carcinoma	GDSC	LPTPSGT	DEG_SCF_FBW7_1	172:178	Mutation altering degron motif	0.6421
p.G177V	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	LPTPSGT	DEG_SCF_FBW7_1	172:178	Mutation altering degron motif	0.6421
p.G177V	SIDM01525	Acute Myeloid Leukemia	GDSC	LPTPSGT	DEG_SCF_FBW7_1	172:178	Mutation altering degron motif	0.6421
p.G166R	SIDM00284	Melanoma	GDSC	LPTPSGT	DEG_SCF_FBW7_1	172:178	Mutation rewiring degron network	0.1667
p.G166R	ACH-000805	Skin Cancer	CCLE	LPTPSGT	DEG_SCF_FBW7_1	172:178	Mutation rewiring degron network	0.1667
p.G166R	COLO-679	skin	COSMIC	LPTPSGT	DEG_SCF_FBW7_1	172:178	Mutation rewiring degron network	0.1667
p.G166E	ACH-001061	Colon/Colorectal Cancer	CCLE	LPTPSGT	DEG_SCF_FBW7_1	172:178	Mutation rewiring degron network	0.1667
p.P175S	ACH-001804	Liposarcoma	CCLE	LPTPSGT	DEG_SCF_FBW7_1	172:178	Mutation altering degron motif	0.6752
p.G165R	COLO-679	skin	COSMIC	LPTPSGT	DEG_SCF_FBW7_1	172:178	Mutation rewiring degron network	0.1389

Kaplan plot for AMTN in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

AMTN

UniProt ID: Q6UX39

Entrez ID: 401138

Protein name: Amelotin

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for AMTN in