DegronMD

Uniprot ID: Q6UX39

Source protein: Amelotin

Source gene: AMTN

Class: DEG_SCF_FBW7_1

Location: 172:178

E3 ligase: FBXW7

DEGRON score: 0.9501

ASA_SCORE: 71

COIL: 0.9284

CONS_SCORE: 0.6504

DSS_SCORE: 0.7334

HELIX: 0.0253

FCONS_SCORE: 0.9452

RIG_SCORE: 0.6117

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P173L	TCGA-AA-3947	COAD	TCGA	LPTPSGT	DEG_SCF_FBW7_1	0.6471
p.P162S	TCGA-D3-A8GS	SKCM	TCGA	LPTPSGT	DEG_SCF_FBW7_1	0.0556
p.Q165H	TCGA-DD-AACJ	LIHC	TCGA	LPTPSGT	DEG_SCF_FBW7_1	0.1389
p.Q165H	TCGA-EE-A29G	SKCM	TCGA	LPTPSGT	DEG_SCF_FBW7_1	0.1389
p.P187S	TCGA-EO-A22U	UCEC	TCGA	LPTPSGT	DEG_SCF_FBW7_1	0.0833
p.V184M	TCGA-FR-A7U9	SKCM	TCGA	LPTPSGT	DEG_SCF_FBW7_1	0.1667
p.V184M	TCGA-ZF-A9R5	BLCA	TCGA	LPTPSGT	DEG_SCF_FBW7_1	0.1667
p.D181N	TCGA-ZF-AA53	BLCA	TCGA	LPTPSGT	DEG_SCF_FBW7_1	0.25
p.D180N	DO219096	BLCA	ICGC	LPTPSGT	DEG_SCF_FBW7_1	0.2778
p.V183M	DO219063	BLCA	ICGC	LPTPSGT	DEG_SCF_FBW7_1	0.1944
p.V183M	DO48546	SKCM	ICGC	LPTPSGT	DEG_SCF_FBW7_1	0.1944
p.P172L	DO8192	COAD	ICGC	LPTPSGT	DEG_SCF_FBW7_1	0.7582
p.P172L	DO220900	MELA	ICGC	LPTPSGT	DEG_SCF_FBW7_1	0.7582
p.R170C	DO227997	COCA	ICGC	LPTPSGT	DEG_SCF_FBW7_1	0.2778
p.Q164H	DO52206	LIHC	ICGC	LPTPSGT	DEG_SCF_FBW7_1	0.1111
p.Q164H	DO47303	SKCM	ICGC	LPTPSGT	DEG_SCF_FBW7_1	0.1111
p.G188S	DO45509	LUSC	ICGC	LPTPSGT	DEG_SCF_FBW7_1	0.0556
p.P174L	DO220886	MELA	ICGC	LPTPSGT	DEG_SCF_FBW7_1	0.7582
p.P186S	DO43755	UCEC	ICGC	LPTPSGT	DEG_SCF_FBW7_1	0.1111
p.R171H	SIDM00232	Kidney Carcinoma	GDSC	LPTPSGT	DEG_SCF_FBW7_1	0.3056
p.R171H	SIDM01622	Breast Carcinoma	GDSC	LPTPSGT	DEG_SCF_FBW7_1	0.3056
p.G177V	SIDM00845	Burkitt's Lymphoma	GDSC	LPTPSGT	DEG_SCF_FBW7_1	0.6421
p.G177V	SIDM00393	Gastric Carcinoma	GDSC	LPTPSGT	DEG_SCF_FBW7_1	0.6421
p.G177V	SIDM00269	Ewing's Sarcoma	GDSC	LPTPSGT	DEG_SCF_FBW7_1	0.6421
p.G177V	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	LPTPSGT	DEG_SCF_FBW7_1	0.6421
p.G177V	SIDM01318	Hepatocellular Carcinoma	GDSC	LPTPSGT	DEG_SCF_FBW7_1	0.6421
p.G177V	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	LPTPSGT	DEG_SCF_FBW7_1	0.6421
p.G177V	SIDM01525	Acute Myeloid Leukemia	GDSC	LPTPSGT	DEG_SCF_FBW7_1	0.6421
p.G166R	SIDM00284	Melanoma	GDSC	LPTPSGT	DEG_SCF_FBW7_1	0.1667
p.G166R	ACH-000805	Skin Cancer	CCLE	LPTPSGT	DEG_SCF_FBW7_1	0.1667
p.G166R	COLO-679	skin	COSMIC	LPTPSGT	DEG_SCF_FBW7_1	0.1667
p.G166E	ACH-001061	Colon/Colorectal Cancer	CCLE	LPTPSGT	DEG_SCF_FBW7_1	0.1667
p.P175S	ACH-001804	Liposarcoma	CCLE	LPTPSGT	DEG_SCF_FBW7_1	0.6752
p.G165R	COLO-679	skin	COSMIC	LPTPSGT	DEG_SCF_FBW7_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LPTPSGT

Degron related mutations and impact score

Drug responses associated with AMTN mutations

All proteins holding degron of LPTPSGT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6UX39	Amelotin	DEG_SCF_FBW7_1	172:178	LPTPSGT	FBXW7	0.9501	More...