DegronMD - Q6UX52(C17orf99)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S106L	DO225208	BRCA	ICGC	LQMHWE	LIG_APCC_ABBA_1	115:120	Mutation rewiring degron network	0.0833
p.R114M	DO222492	COCA	ICGC	LQMHWE	LIG_APCC_ABBA_1	115:120	Mutation rewiring degron network	0.3056
p.L121V	DO229010	COCA	ICGC	LQMHWE	LIG_APCC_ABBA_1	115:120	Mutation rewiring degron network	0.3056
p.L121V	DO229480	LAML	ICGC	LQMHWE	LIG_APCC_ABBA_1	115:120	Mutation rewiring degron network	0.3056
p.L121V	DO229047	LICA	ICGC	LQMHWE	LIG_APCC_ABBA_1	115:120	Mutation rewiring degron network	0.3056
p.L121V	DO52365	LUSC	ICGC	LQMHWE	LIG_APCC_ABBA_1	115:120	Mutation rewiring degron network	0.3056
p.L121V	DO231072	LUSC	ICGC	LQMHWE	LIG_APCC_ABBA_1	115:120	Mutation rewiring degron network	0.3056
p.A113S	DO229015	LICA	ICGC	LQMHWE	LIG_APCC_ABBA_1	115:120	Mutation rewiring degron network	0.2778
p.E128D	DO229041	LICA	ICGC	LQMHWE	LIG_APCC_ABBA_1	115:120	Mutation rewiring degron network	0.1111
p.W119G	DO234031	THCA	ICGC	LQMHWE	LIG_APCC_ABBA_1	115:120	Mutation altering degron motif	0.6714
p.R114S	ACH-001513	Cervical Cancer	CCLE	LQMHWE	LIG_APCC_ABBA_1	115:120	Mutation rewiring degron network	0.3056

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons