DegronMD

Uniprot ID: Q6UX52

Source protein: Protein IL-40

Source gene: C17orf99

Class: LIG_APCC_ABBA_1

Location: 115:120

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.726

ASA_SCORE: 54.3167

COIL: 0.1478

CONS_SCORE: 0.8645

DSS_SCORE: 0.1857

HELIX: 0.0137

FCONS_SCORE: 1.3041

RIG_SCORE: 0.8454

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S106L	DO225208	BRCA	ICGC	LQMHWE	LIG_APCC_ABBA_1	0.0833
p.R114M	DO222492	COCA	ICGC	LQMHWE	LIG_APCC_ABBA_1	0.3056
p.L121V	DO229010	COCA	ICGC	LQMHWE	LIG_APCC_ABBA_1	0.3056
p.L121V	DO229480	LAML	ICGC	LQMHWE	LIG_APCC_ABBA_1	0.3056
p.L121V	DO229047	LICA	ICGC	LQMHWE	LIG_APCC_ABBA_1	0.3056
p.L121V	DO52365	LUSC	ICGC	LQMHWE	LIG_APCC_ABBA_1	0.3056
p.L121V	DO231072	LUSC	ICGC	LQMHWE	LIG_APCC_ABBA_1	0.3056
p.A113S	DO229015	LICA	ICGC	LQMHWE	LIG_APCC_ABBA_1	0.2778
p.E128D	DO229041	LICA	ICGC	LQMHWE	LIG_APCC_ABBA_1	0.1111
p.W119G	DO234031	THCA	ICGC	LQMHWE	LIG_APCC_ABBA_1	0.6714
p.R114S	ACH-001513	Cervical Cancer	CCLE	LQMHWE	LIG_APCC_ABBA_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6UX52	Protein IL-40	LIG_APCC_ABBA_1	115:120	LQMHWE	APC,CDC20,FZR1	0.726	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons