DegronMD - Q6UXI9(NPNT)

NPNT

UniProt ID: Q6UXI9

Entrez ID: 255743

Protein name: Nephronectin (Preosteoblast EGF-like repeat protein with MAM domain) (Protein EGFL6-like)

External links: UniprotKB HGNC RefSeq COSMIC

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GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P373T	TCGA-B0-4706	KIRC	TCGA	IAPAASTPPGGITV	DEG_ODPH_VHL_1	357:370	Mutation rewiring degron network	0.25
p.T349A	TCGA-CG-5728	STAD	TCGA	IAPAASTPPGGITV	DEG_ODPH_VHL_1	357:370	Mutation rewiring degron network	0.1111
p.P356S	TCGA-EE-A29Q	SKCM	TCGA	IAPAASTPPGGITV	DEG_ODPH_VHL_1	357:370	Mutation rewiring degron network	0.3056
p.P356S	TCGA-ER-A3PL	SKCM	TCGA	IAPAASTPPGGITV	DEG_ODPH_VHL_1	357:370	Mutation rewiring degron network	0.3056
p.E378K	TCGA-FR-A726	SKCM	TCGA	IAPAASTPPGGITV	DEG_ODPH_VHL_1	357:370	Mutation rewiring degron network	0.1111
p.P359L	TCGA-FS-A1ZK	SKCM	TCGA	IAPAASTPPGGITV	DEG_ODPH_VHL_1	357:370	Mutation altering degron motif	0.7582
p.R379K	TCGA-RP-A695	SKCM	TCGA	IAPAASTPPGGITV	DEG_ODPH_VHL_1	357:370	Mutation rewiring degron network	0.0833
p.G353R	DO1285	BRCA	ICGC	IAPAASTPPGGITV	DEG_ODPH_VHL_1	357:370	Mutation rewiring degron network	0.2222
p.G353R	MEL-JUSO	skin	COSMIC	IAPAASTPPGGITV	DEG_ODPH_VHL_1	357:370	Mutation rewiring degron network	0.2222
p.V374L	DO229045	LICA	ICGC	IAPAASTPPGGITV	DEG_ODPH_VHL_1	357:370	Mutation rewiring degron network	0.2222
p.Q379H	DO23732	LUAD	ICGC	IAPAASTPPGGITV	DEG_ODPH_VHL_1	357:370	Mutation rewiring degron network	0.0833
p.S362T	DO23557	LUAD	ICGC	IAPAASTPPGGITV	DEG_ODPH_VHL_1	357:370	Mutation altering degron motif	0.6005
p.G353E	DO222662	MELA	ICGC	IAPAASTPPGGITV	DEG_ODPH_VHL_1	357:370	Mutation rewiring degron network	0.2222
p.E348K	DO48665	SKCM	ICGC	IAPAASTPPGGITV	DEG_ODPH_VHL_1	357:370	Mutation rewiring degron network	0.0833
p.G367W	DO37961	SKCM	ICGC	IAPAASTPPGGITV	DEG_ODPH_VHL_1	357:370	Mutation altering degron motif	0.6714
p.R349K	DO51270	SKCM	ICGC	IAPAASTPPGGITV	DEG_ODPH_VHL_1	357:370	Mutation rewiring degron network	0.1111
p.T366K	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	IAPAASTPPGGITV	DEG_ODPH_VHL_1	357:370	Mutation altering degron motif	0.7306
p.T366K	ACH-000916	Lung Cancer	CCLE	IAPAASTPPGGITV	DEG_ODPH_VHL_1	357:370	Mutation altering degron motif	0.7306
p.T366K	NCI-H1573	lung	COSMIC	IAPAASTPPGGITV	DEG_ODPH_VHL_1	357:370	Mutation altering degron motif	0.7306
p.K351N	SIDM01519	Head and Neck Carcinoma	GDSC	IAPAASTPPGGITV	DEG_ODPH_VHL_1	357:370	Mutation rewiring degron network	0.1667
p.P350A	ACH-001396	Metastasis	CCLE	IAPAASTPPGGITV	DEG_ODPH_VHL_1	357:370	Mutation rewiring degron network	0.1389
p.T353K	NCI-H1573	lung	COSMIC	IAPAASTPPGGITV	DEG_ODPH_VHL_1	357:370	Mutation rewiring degron network	0.2222
p.L364M	RXF393	kidney	COSMIC	IAPAASTPPGGITV	DEG_ODPH_VHL_1	357:370	Mutation altering degron motif	0.711
p.L351M	RXF393	kidney	COSMIC	IAPAASTPPGGITV	DEG_ODPH_VHL_1	357:370	Mutation rewiring degron network	0.1667
p.T355A	NCI-H1792	lung	COSMIC	IAPAASTPPGGITV	DEG_ODPH_VHL_1	357:370	Mutation rewiring degron network	0.2778
p.P365Q	COLO-741	large intestine	COSMIC	IAPAASTPPGGITV	DEG_ODPH_VHL_1	357:370	Mutation altering degron motif	0.5924
p.G370R	MEL-JUSO	skin	COSMIC	IAPAASTPPGGITV	DEG_ODPH_VHL_1	357:370	Mutation altering degron motif	0.7568
p.T372A	NCI-H1792	lung	COSMIC	IAPAASTPPGGITV	DEG_ODPH_VHL_1	357:370	Mutation rewiring degron network	0.2778

Kaplan plot for NPNT in

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*NOTE: the Kaplan plots were collected from OncoLnc